ANTIMICROBIAL PEPTIDES IN SEPSIS: A SYSTEMIC APPROACH

• Grant number: 15/00892-4
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2016
• End date: June 30, 2018
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Fabiano Pinheiro da Silva
• Grantee: Fabiano Pinheiro da Silva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Denise Frediani Barbeiro ; Eduardo Moraes Rego Reis ; Heraldo Possolo de Souza ; Hermes Vieira Barbeiro ; Irineu Tadeu Velasco ; Marcel Cerqueira Cesar Machado ; Patricia Severino ; Thais Martins de Lima Salgado

Abstract

Sepsis is the leading cause of death in patients admitted to intensive care units (ICUs). Antimicrobial peptides (AMPs) are key molecules of innate immunity and their role is poorly understood in sepsis. In this study, we will induce septic shock in wild-type and CRAMP-deficiente mice. The biological material obtained by this strategy will be used in Transcriptomics experiments. As a result, we believe that important molecular mechanisms of this disease will be described. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, FABIANO PINHEIRO; CESAR MACHADO, MARCEL CERQUEIRA. The dual role of cathelicidins in systemic inflammation. Immunology Letters, v. 182, p. 57-60, FEB 2017. (15/00892-4)

SEVERINO, PATRICIA; ARIGA, SUELY KUBO; BARBEIRO, HERMES VIEIRA; DE LIMA, THAIS MARTINS; SILVA, ELISANGELA DE PAULA; BARBEIRO, DENISE FREDIANI; CESAR MACHADO, MARCEL CERQUEIRA; NIZET, VICTOR; DA SILVA, FABIANO PINHEIRO. Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 95, n. 9, p. 995-1003, SEP 2017. (15/00892-4)