AIDS' NUTRITION METABOLIC IMPACT: Relationship between lipodystrophy, body composition, metabolic profile and serum levels of adipocytokines.

• Grant number: 15/10103-7
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2016
• End date: November 30, 2018
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Sílvia Justina Papini
• Grantee: Sílvia Justina Papini
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: José Eduardo Corrente ; Paulo Câmara Marques Pereira
• Associated scholarship(s): 18/05453-7 - AIDS' nutrition metabolic impact: relationship between lipodystrophy, body composition, metabolic profile and serum levels of adipocytokines, BP.TT

Abstract

The relationship between nutrition and immune function in aids is well known. The evolution of HIV infection usually alters metabolic and nutritional factors. The specific treatment for this condition is critical and dramatically reduces morbidity and mortality. Due to the decrease in the opportunistic infections' frequency, we observed a transition of nutritional status of these patients, previously characterized by intense weight loss and malnutrition (or "Wasting Syndrome"); by excessive weight gain, which makes them overweight or obese individuals, even after antiretroviral therapy (ART). Despite the benefits at clinical state improvement of people living with HIV/aids, some side effects associated with the use of ART are reported. The redistribution of body fat has been associated with the treatment and is characterized by morphological changes, also known as lipodystrophy. The complications of metabolic and morphological changes in these individuals carry aesthetic consequences, in addition to increasing the risk of cardiovascular and pancreatic diseases development. Thereby, it is oriented that the nutritional assessment is accurate not only to measure the change in total body weight, but to quantify and locate the distribution of fat accumulation as well. The adipocytokines are proteins with essential functions to biological processes, wherein these proteins' levels are related to the pathogenesis of the metabolic syndrome and cardiovascular disease. Recent studies have shown that such levels are usually modified in people living with HIV/AIDS, regardless of whether the treatment is established or not. An application of methods for body fat estimation on patients with fat redistribution, as in the case of AIDS, especially those that quantify body fat by segments. This is an important indicator of nutritional assessment in order to define, in clinical practice, the most appropriate treatment for the prevention of comorbidities. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SACILOTTO, LIVIA BERTAZZO; PEREIRA, PAULO CAMARA MARQUES; MENDES, ADRIANA LUCIA; CORRENTE, JOSE EDUARDO; MANECHINI, JOAO PAULO VIEIRA; PAPINI, JUSTINA SILVIA. BODY COMPOSITION, ANTHROPOMETRIC MEASURES AND CLINICAL-NUTRITIONAL PARAMETERS OF PEOPLE LIVING WITH HIV/AIDS WITH CLINICAL DIAGNOSES OF HIV-ASSOCIATED LIPODYSTROPHY SYNDROME SUBDIVIDED BY GENDER. ANNALS OF NUTRITION AND METABOLISM, v. 71, p. 1-pg., 2017-01-01. (15/10103-7)

PAPINI, JUSTINA SILIVIA; SACILOTTO, LIVIA BERTAZZO; MENDES, ADRIANA LUCIA; CORRENTE, JOSE EDUARDO; MANECHINI, JOAO PAULO VIEIRA; PAULO, PAULO CMARA MARQUES. BODY COMPOSITION, ANTHROPOMETRIC MEASURES AND CLINICAL-NUTRITIONAL PARAMETERS OF PEOPLE LIVING WITH HIV/AINDS WITH CLINICAL DIAGNOSES OF HIV-ASSOCIATED LIPODYSTROPHY SYNDROME SUBDIVIDED BY GENDER. ANNALS OF NUTRITION AND METABOLISM, v. 71, p. 1-pg., 2017-01-01. (15/10103-7)

PAPINI, JUSTINA SILVIA; SACILOTTO, LIVIA BERTAZZO; MENDES, ADRIANA LUCIA; CORRENTE, JOSE EDUARDO; MANECHINI, JOAO PAULO VIEIRA; PEREIRA, PAULO CAMARA MARQUES. BODY COMPOSITION OF PEOPLE LIVING WITH HIV/AIDS WITH CLINICAL DIAGNOSES OH HIV-RELATED LIPODYSTROPHY SYNDROME. ANNALS OF NUTRITION AND METABOLISM, v. 71, p. 2-pg., 2017-01-01. (15/10103-7)

SACILOTTO, LIVIA BERTAZZO; PEREIRA, PAULO CAMARA MARQUES; MENDES, ADRIANA LUCIA; CORRENTE, JOSE EDUARDO; MANECHINI, JOAO PAULO VIEIRA; JUSTINA, PAPINI SILVIA. CORRELATION BETWEEN ANTHROPOMETRIC AND BODY COMPOSITION INDICATORS OF PEOPLE LIVING WITH HIV/AIDS WITH HIV ASSOCIATED LIPODYSTROPHY CLINIC DIAGNOSES. ANNALS OF NUTRITION AND METABOLISM, v. 71, p. 1-pg., 2017-01-01. (15/10103-7)

SACILOTTO, LIVIA BERTAZZO; PAPINI, SILVIA JUSTINA; MENDES, ADRIANA LUCIA; GATTO, MARIANA; PEREIRA, PAULO CAMARA MARQUES; CORRENTE, JOSE EDUARDO; DA SILVA, JULHIANY DE FATIMA. Relationship Between Lipodystrophy, Body Composition, Metabolic Profile, and Serum Levels of Adipocytokines. FRONTIERS IN NUTRITION, v. 8, DEC 9 2021. (15/10103-7)