LbL (LAYER-BY-LAYER) and Langmuir-Blodgett (LB) nanostructured films with emodin for systems carriers.

• Grant number: 16/19387-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2017
• End date: May 31, 2019
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Marystela Ferreira
• Grantee: Marystela Ferreira
• Host Institution: Centro de Ciências e Tecnologias para a Sustentabilidade (CCTS). Universidade Federal de São Carlos (UFSCAR). Sorocaba , SP, Brazil

Abstract

This project aims to study the incorporation of drugs into nanocarriers, for immobilization of the pharmac on LbL film (Layer-by-Layer) and LB (Langmuir-Blodgett) film for the purpose of controlled release. The drug was chosen to be immobilized is emodin on LbL and LB film in free form or incorporated into liposomes and / or cyclodextrins. The systems are characterized by spectroscopy in the ultraviolet and visible (UV-vis) spectroscopy, infrared Fourier transform (FTIR) analysis and tracking nanoparticle (NTA Nanoparticle tracking analyzes), dynamic light scattering (DLS Dynamic Light Scattering), and electrochemical techniques. The films are also characterized by surface plasmon resonance (SPR) allows to determine its thickness and investigate molecular interactions between the constituents. The association emodin the nanostructured films opens perspectives for use in the controlled release of drugs control systems that mimic the lipid layer of the skin model. (AU)

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LIMA, LUCAS F.; DAIKUZONO, CRISTIANE M.; MIYAZAKI, CELINA M.; PEREIRA, ELISABETE A.; FERREIRA, MARYSTELA. Layer-by-Layer nanostructured films of magnetite nanoparticles and polypyrrole towards synergistic effect on methylparaben electrochemical detection. Applied Surface Science, v. 505, MAR 1 2020. (14/15093-7, 18/04061-8, 16/19387-0, 11/23286-1)

CAMPOS, PAULA P.; FRACETO, LEONARDO FERNANDES; FERREIRA, MARYSTELA. Layer-by-layer films containing emodin or emodin encapsulated in liposomes for transdermal applications. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 162, p. 69-75, FEB 1 2018. (16/19387-0)

DE LIMA, LUCAS F.; PEREIRA, ELISABETE A.; FERREIRA, MARYSTELA. Electrochemical sensor for propylparaben using hybrid Layer-by-Layer films composed of gold nanoparticles, poly(ethylene imine) and nickel(II) phthalocyanine tetrasulfonate. SENSORS AND ACTUATORS B-CHEMICAL, v. 310, MAY 1 2020. (14/15093-7, 16/19387-0, 18/04061-8)

MIYAZAKI, CELINA MASSUMI; CAMILO, DOUGLAS ELEUTERIO; SHIMIZU, FLAVIO MAKOTO; FERREIRA, MARYSTELA. Improved antibody loading on self-assembled graphene oxide films for using in surface plasmon resonance immunosensors. Applied Surface Science, v. 490, p. 502-509, OCT 1 2019. (14/15093-7, 16/19387-0, 14/50869-6)

CAMILO, DOUGLAS E.; MIYAZAKI, CELINA M.; SHIMIZU, FLAVIO M.; FERREIRA, MARYSTELA. Improving direct immunoassay response by layer-by-layer films of gold nanoparticles - Antibody conjugate towards label-free detection. Materials Science & Engineering C-Materials for Biological Applications, v. 102, p. 315-323, SEP 2019. (14/15093-7, 14/50869-6, 16/19387-0)

DE LIMA, LUCAS F.; MACIEL, CRISTIANE C.; FERREIRA, ANDRE L.; DE ALMEIDA, JESSICA C.; FERREIRA, MARYSTELA. Nickel (II) phthalocyanine-tetrasulfonic-Au nanoparticles nanocomposite film for tartrazine electrochemical sensing. Materials Letters, v. 262, MAR 1 2020. (14/15093-7, 16/19387-0, 18/04061-8)

MAGALHAES IERICH, JESSICA CRISTIANE; BRUM, DORALINA GUIMARAES; MORAES, ARIANA DE SOUZA; HIGA, AKEMI MARTINS; GARCIA, PAMELA SOTO; MIYAZAKI, CELINA MASSUMI; FERREIRA, MARYSTELA; PERONI, LUIS ANTONIO; DE OLIVEIRA, GUEDMILLER SOUZA; FRANCA, EDUARDO DE FARIA; et al. Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes. SCIENTIFIC REPORTS, v. 9, FEB 14 2019. (13/09746-5, 14/12082-4, 14/15093-7, 14/21530-0, 12/50839-4, 15/05283-6, 14/26369-3, 14/50869-6, 15/06847-0, 16/19387-0)

DE LIMA, LUCAS FELIPE; FERREIRA, ANDRE LOPES; DE FREITAS, AMANDA DE SOUSA MARTINEZ; RODRIGUES, JESSICA DE SOUZA; LEMES, ANA PAULA; FERREIRA, MARYSTELA; DE ARAUJO, WILLIAM REIS. Biodegradable and Flexible Thermoplastic Composite Graphite Electrodes: A Promising Platform for Inexpensive and Sensitive Electrochemical Detection of Creatine Kinase at the Point-of-Care. ACS APPLIED MATERIALS & INTERFACES, v. 15, n. 15, p. 13-pg., 2023-04-04. (20/12659-0, 16/19387-0, 19/02692-3, 22/03250-7, 18/08782-1, 18/04061-8)

FERREIRA, ANDRE L.; DE LIMA, LUCAS F.; MORAES, ARIANA S.; RUBIRA, RAFAEL J. G.; CONSTANTINO, CARLOS J. L.; LEITE, FABIO L.; DELGADO-SILVA, ADRIANA O.; FERREIRA, MARYSTELA. Development of a novel biosensor for Creatine Kinase (CK-MB) using Surface Plasmon Resonance (SPR). Applied Surface Science, v. 554, p. 9-pg., 2021-03-26. (16/19387-0, 18/04061-8, 19/02692-3, 14/50869-6)

MIYAZAKI, CELINA M.; ADRIANO, ANGELA M.; RUBIRA, RAFAEL J. G.; CONSTANTINO, CARLOS J. L.; FERREIRA, MARYSTELA. Combining electrochemically reduced graphene oxide and Layer-by-Layer films of magnetite nanoparticles for carbofuran detection. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 8, n. 5, p. 9-pg., 2020-10-01. (16/19387-0, 14/15093-7, 16/09634-0, 13/14262-7, 17/19630-5)

MORAES, ARIANA DE SOUZA; BRUM, DORALINA GUIMARAES; MAGALHAES IERICH, JESSICA CRISTIANE; HIGA, AKEMI MARTINS; JABUR ASSIS, AMANDA STEFANIE; MIYAZAKI, CELINA MASSUMI; SHIMIZU, FLAVIO MAKOTO; PERONI, LUIS ANTONIO; MACHINI, M. TERESA; BARREIRA, AMILTON ANTUNES; et al. A highly specific and sensitive nanoimmunosensor for the diagnosis of neuromyelitis optica spectrum disorders. SCIENTIFIC REPORTS, v. 9, NOV 6 2019. (16/19387-0, 14/50869-6, 13/14262-7, 14/15093-7, 12/50839-4, 14/12082-4, 15/05283-6, 15/06847-0, 15/14360-4)

DE ALMEIDA, JESSICA CRISTINA; DE BARROS, ANERISE; MAZALI, ITALO ODONE; FERREIRA, MARYSTELA. Influence of gold nanostructures incorporated into sodium montmorillonite clay based on LbL films for detection of metal traces ions. Applied Surface Science, v. 507, MAR 30 2020. (16/19387-0)

RODRIGUES, GUSTAVO H. S.; MIYAZAKI, CELINA M.; RUBIRA, RAFAEL J. G.; CONSTANTINO, CARLOS J. L.; FERREIRA, MARYSTELA. Layer-by-Layer Films of Graphene Nanoplatelets and Gold Nanoparticles for Methyl Parathion Sensing. ACS APPLIED NANO MATERIALS, v. 2, n. 2, p. 1082-1091, FEB 2019. (14/15093-7, 16/09634-0, 16/19387-0, 17/03523-5)

DE LIMA, LUCAS F.; MACIEL, CRISTIANE C.; FERREIRA, ANDRE L.; RUBIRA, RAFAEL J. G.; CONSTANTINO, CARLOS J. L.; FERREIRA, MARYSTELA. An investigation of the synergistic effect between magnetite nanoparticles and polypyrrole in nanostructured layer-by-layer films. Journal of Applied Polymer Science, v. 138, n. 5, AUG 2020. (16/09634-0, 18/04061-8, 16/19387-0)