Development and characterization of delivery systems containing docetaxel for optimization of prostate cancer therapy: imunoliposomes and polymeric nanoparticles

• Grant number: 17/04091-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2017
• End date: August 31, 2019
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Juliana Maldonado Marchetti
• Grantee: Juliana Maldonado Marchetti
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Prostate cancer is the most prevalent type of cancer in men, but its therapy is associated with many effects and limited effectiveness. Docetaxel is one of the first choice antitumor drugs used in conventional therapy for several types of cancer - including prostate - but it presents severe side effects. Pharmaceutical technology has been using important strategies for the purpose of turning cancer therapy more efficient and less aggressive to normal cells, situation where nanostructured release systems stand out. The present study aims to develop and evaluate the efficacy of two different nanostructured release systems containing docetaxel against prostate cancer cell lines. Polymeric nanoparticles and immunoliposomes will be developed and characterized by their physico-chemical and morphological characteristics. The in vitro cytotoxicity will be evaluated by different techniques and in distinct lines of prostate cancer cells, allowing a set of formulations and conclusions on the viability of each one of them. Finally, efficacy studies using xenotransplantation model in immunosuppressed mice will be conducted. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RASPANTINI, GIOVANNI LOUREIRO; LUIZ, MARCELA TAVARES; ABRIATA, JULIANA PALMA; ELOY, JOSIMAR DE OLIVEIRA; VAIDERGORN, MIGUEL MENEZES; DA SILVA EMERY, FLAVIO; MARCHETTI, JULIANA MALDONADO. PCL-TPGS polymeric nanoparticles for docetaxel delivery to prostate cancer: Development, physicochemical and biological characterization. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 627, OCT 20 2021. (16/03013-4, 17/04091-1)

JULIANA PALMA ABRIATA; MARCELA TAVARES LUIZ; JULIANA SANTOS ROSA VIEGAS; FERNANDO FUMAGALLI; SHAIANI MARIA GILDE MELO; FLAVIO DA SILVA EMERY; JULIANA MALDONADO MARCHETTI; FABIANA TESTA MOURA DE CARVALHO VICENTINI. Poly-ε-caprolactone based nanoparticles for delivery of genistein in melanoma treatment. Brazilian Journal of Pharmaceutical Sciences, v. 60, 2024-02-26. (17/04091-1)

ELOY, JOSIMAR O.; RUIZ, AMALIA; DE LIMA, FELIPE TITA; PETRILLI, RAQUEL; RASPANTINI, GIOVANNI; BARROS NOGUEIRA, KARINA ALEXANDRE; SANTOS, ELIAS; DE OLIVEIRA, CARLOS SABINO; BORGES, JULIO CESAR; MARCHETTI, JULIANA MALDONADO; et al. EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 194, p. 12-pg., 2020-10-01. (18/21104-2, 18/00814-1, 17/04091-1, 16/02723-8)