| Grant number: | 14/21185-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2017 |
| End date: | September 30, 2019 |
| Field of knowledge: | Health Sciences - Physical Education |
| Principal Investigator: | Elaine Hatanaka Dermargos |
| Grantee: | Elaine Hatanaka Dermargos |
| Host Institution: | Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Cruzeiro do Sul (UNICSUL). São Paulo , SP, Brazil |
| Associated researchers: | Alexandre Dermargos Oliveira ; Leandro da Silva Borges |
Abstract
The genesis and progression of diabetes occur, in part, due to increased pro-inflammatory cytokines, free fatty acids and leukocyte dysfunctions presented by diabetic patients. The exercise of moderate intensity is indicated for therapeutic and preventive purposes in a number of diseases, including diabetes. In addition to the metabolic and cardiovascular benefits, moderateintensity exercise, when practiced regularly can improve the responsiveness of immune cells in healthy people. The aim of this study is to investigate the effects of four months of physical training with dance, at moderate intensity (60 % VO2max, 60 min/day, 2 days/week) on plasma concentrations of inflammatory markers and leukocytes functions in type 2 diabetic subjects. The function of neutrophils (release of reactive oxygen species and cytokines) will be evaluated as well as the occurrence and type of death of these cells (apoptosis and or necrosis). Blood samples will be collected from the groups (control and diabetic) before and after physical training of 4 months. Diabetic patients will be recruited in ANAD (National Association of Diabetes Care). Glycemic control will be achieved by measures of blood glucose and glycated hemoglobin. The proinflammatory cytokines are quantified by ELISA. The concentration of glycated hemoglobin, glucose and free fatty acids will be determined by the enzymatic colorimetric method and PCR will be determined by immunoturbidimetric method. The occurrence of cell death and the production of reactive oxygen species will be analyzed by flow cytometry. (AU)
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