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Development and validation of analytical methods for the determination of streptomycin and dihydrostreptomycin residues in milk (ELISA, LC-APCI-MS/MS QToF)

Grant number: 07/02233-1
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2007
Effective date (End): July 31, 2009
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal researcher:Felix Guillermo Reyes Reyes
Grantee:Renata Cabrera de Oliveira
Home Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


In order to implement measurements of sanitary surveillance to the presence of antimicrobials residues, in foods of animal origin intended to human consumption, it is necessary to develop analytical methods that shown adequate selectivity and detectability for determination of these residues. Therefore, the aim of this project is to optimize and validate analytical methods for the determination of streptomycin and dihydrostreptomycin residues in milk using enzyme linked immuno sorbent assay, high performance liquid chromatography and liquid chromatography with tandem mass spectrometry. Pasteurized milk samples commercialized in the region of Campinas, São Paulo will be analysed. The following performance criteria will be evaluated: linearity; and linear range, sensitivity, selectivity or specificity; accuracy; intra-assay (repeatability) and inter-assay (reproducibility) precision; detection and quantitation limits of the method and ruggedness.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Renata Cabrera de. Development and validation of analytical methos for the determination of streptomycin and ddihydrostreptomycin residues in milk (ELISA, LC-APCI-MS/MS QToF). 2009. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia de Alimentos.

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