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Effects of creatine supplementation on homocysteine and oxidative stress after aerobic and anaerobic acute exercise in rats

Grant number: 07/08099-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2008
Effective date (End): February 28, 2010
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Alceu Afonso Jordão Junior
Grantee:Rafael Deminice
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Many evidences have shown a link between high levels of homocysteine (Hcy) and a range of diseases, besides is considered an independent risk factor for cardiovascular disease. Moreover, the hyperhomocysteinemia (HHcy) is directly linked to the reactive oxygen species (ROS) formation may cause lipid peroxidation and cellular damage. Recent studies have shown that the acute physical effort increase the protein metabolism and change plasma concentrations of certain aminoacids. Thus, the metabolism of Hcy and the formation of ROS can be changed by the increase or decrease in the methionine catabolism and/or metil groups turnover induced by physical effort. However, the relationship between the intensity of physical effort and Hcy metawbolismo is still little known. The creatine synthesis is responsible for the majority of metil groups transfer in normal hepatic metabolism. As Hcy is an aminoacid formed exclusively from the demethylation of methionine, it is believed that the high rate of creatine synthesis is the primary responsible for the homocysteine blood levels increase. Furthermore, the creatine supplementation can suppress the creatine synthesis inhibiting the expression of the enzyme arginine:glycine amidinotransferase, besides possible antioxidant capacity reported by some authors. Thus, is goal of this research project to investigate the effects of creatine supplementation on homocisteína concentration and lipid peroxidation after aerobic and anaerobic acute exercise in rats.

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEMINICE, RAFAEL; DA SILVA, ROBIN P.; LAMARRE, SIMON G.; KELLY, KAREN B.; JACOBS, RENE L.; BROSNAN, MARGARET E.; BROSNAN, JOHN T. Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. Amino Acids, v. 47, n. 4, p. 839-846, APR 2015. Web of Science Citations: 29.
DEMINICE, RAFAEL; JORDAO, ALCEU AFONSO. Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats. Amino Acids, v. 43, n. 2, p. 709-715, AUG 2012. Web of Science Citations: 25.
DEMINICE, RAFAEL; VANNUCCHI, HELIO; SIMOES-AMBROSIO, LIVIA MARIA; JORDAO, ALCEU AFONSO. Creatine supplementation reduces increased homocysteine concentration induced by acute exercise in rats. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 111, n. 11, p. 2663-2670, NOV 2011. Web of Science Citations: 17.
DEMINICE, RAFAEL; DA SILVA, ROBIN P.; LAMARRE, SIMON G.; BROWN, COLIN; FUREY, GEORGE N.; MCCARTER, SHANNON A.; JORDAO, ALCEU AFONSO; KELLY, KAREN B.; KING-JONES, KIRST; JACOBS, RENE L.; BROSNAN, MARGARET E.; BROSNAN, JOHN T. Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet. Journal of Nutrition, v. 141, n. 10, p. 1799-1804, OCT 2011. Web of Science Citations: 36.
DEMINICE, RAFAEL; SICCHIERI, TIAGO; MIALICH, MIRELE S.; MILANI, FRANCINE; OVIDIO, PAULA P.; JORDAO, ALCEU A. OXIDATIVE STRESS BIOMARKER RESPONSES TO AN ACUTE SESSION OF HYPERTROPHY-RESISTANCE TRADITIONAL INTERVAL TRAINING AND CIRCUIT TRAINING. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 25, n. 3, p. 798-804, MAR 2011. Web of Science Citations: 15.
DEMINICE, R.; SICCHIERI, T.; PAYAO, P. O.; JORDAO, A. A. Blood and Salivary Oxidative Stress Biomarkers Following an Acute Session of Resistance Exercise in Humans. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 31, n. 9, p. 599-603, SEP 2010. Web of Science Citations: 21.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.