Many evidences have shown a link between high levels of homocysteine (Hcy) and a range of diseases, besides is considered an independent risk factor for cardiovascular disease. Moreover, the hyperhomocysteinemia (HHcy) is directly linked to the reactive oxygen species (ROS) formation may cause lipid peroxidation and cellular damage. Recent studies have shown that the acute physical effort increase the protein metabolism and change plasma concentrations of certain aminoacids. Thus, the metabolism of Hcy and the formation of ROS can be changed by the increase or decrease in the methionine catabolism and/or metil groups turnover induced by physical effort. However, the relationship between the intensity of physical effort and Hcy metawbolismo is still little known. The creatine synthesis is responsible for the majority of metil groups transfer in normal hepatic metabolism. As Hcy is an aminoacid formed exclusively from the demethylation of methionine, it is believed that the high rate of creatine synthesis is the primary responsible for the homocysteine blood levels increase. Furthermore, the creatine supplementation can suppress the creatine synthesis inhibiting the expression of the enzyme arginine:glycine amidinotransferase, besides possible antioxidant capacity reported by some authors. Thus, is goal of this research project to investigate the effects of creatine supplementation on homocisteína concentration and lipid peroxidation after aerobic and anaerobic acute exercise in rats.
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