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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

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Deminice, Rafael [1, 2] ; da Silva, Robin P. [1] ; Lamarre, Simon G. [1] ; Brown, Colin ; Furey, George N. [1] ; McCarter, Shannon A. [1] ; Jordao, Alceu Afonso [2] ; Kelly, Karen B. [3, 4] ; King-Jones, Kirst [5] ; Jacobs, Rene L. [3, 4] ; Brosnan, Margaret E. [1] ; Brosnan, John T. [1]
Total Authors: 12
[1] Mem Univ Newfoundland, Dept Biochem, St John, NF - Canada
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Lab Nutr & Metab, Sao Paulo - Brazil
[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB - Canada
[4] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB - Canada
[5] Univ Alberta, Dept Biol Sci, Edmonton, AB - Canada
Total Affiliations: 5
Document type: Journal article
Source: Journal of Nutrition; v. 141, n. 10, p. 1799-1804, OCT 2011.
Web of Science Citations: 36

The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of L-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPAR as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of beta-oxidation. J. Nutr. 141: 1799-1804, 2011. (AU)

FAPESP's process: 07/08099-5 - Effects of creatine supplementation on homocysteine and oxidative stress after aerobic and anaerobic acute exercise in rats
Grantee:Rafael Deminice
Support type: Scholarships in Brazil - Doctorate