| Full text | |
| Author(s): Show less - |
Deminice, Rafael
[1, 2]
;
da Silva, Robin P.
[1]
;
Lamarre, Simon G.
[1]
;
Brown, Colin
;
Furey, George N.
[1]
;
McCarter, Shannon A.
[1]
;
Jordao, Alceu Afonso
[2]
;
Kelly, Karen B.
[3, 4]
;
King-Jones, Kirst
[5]
;
Jacobs, Rene L.
[3, 4]
;
Brosnan, Margaret E.
[1]
;
Brosnan, John T.
[1]
Total Authors: 12
|
| Affiliation: | [1] Mem Univ Newfoundland, Dept Biochem, St John, NF - Canada
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Lab Nutr & Metab, Sao Paulo - Brazil
[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB - Canada
[4] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB - Canada
[5] Univ Alberta, Dept Biol Sci, Edmonton, AB - Canada
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Journal of Nutrition; v. 141, n. 10, p. 1799-1804, OCT 2011. |
| Web of Science Citations: | 36 |
| Abstract | |
The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of L-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPAR as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of beta-oxidation. J. Nutr. 141: 1799-1804, 2011. (AU) | |
| FAPESP's process: | 07/08099-5 - Effects of creatine supplementation on homocysteine and oxidative stress after aerobic and anaerobic acute exercise in rats |
| Grantee: | Rafael Deminice |
| Support type: | Scholarships in Brazil - Doctorate |