Influence of gastrointestinal motility under the disintegration process of tablets using AC biosusceptometry

• Grant number: 06/06489-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2007
• End date: June 30, 2010
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: José Ricardo de Arruda Miranda
• Grantee: Uilian de Andreis
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Oral administration of solid dosage forms is usually preferred in drug therapy. The analysis of the disintegration process is fundamental for the quality control of the pharmaceutical industry. The disintegration process depends on several parameters and its evaluation should be accomplished in vivo by non-invasive methodologies. Nevertheless, very little is known about the influence of the gastrointestinal motility on the pharmaceutical forms when an in vivo measurement is performed. In this study the innovative and non-invasive ACB will be employed to evaluate the behavior of magnetic tablets in vivo when agents that affect gastrointestinal motility are used as model to verify modifications in the disintegration time, retention time and intestinal transit time of coated tablets. Besides that, blood samples analyzed by HPLC will correlate the physical disintegration process with the pharmacokinetic analysis of drug absorption, so-called magnetopharmacokinetic.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ANDREIS, Uilian de. Farmacomagnetografia colônia: estudo in vitro da desintegração de comprimidos magnéticos revestidos. 2010. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.