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Process analysis of alveolar repair in spontaneously hypertensive rats (SHR) untreated and treated with losartan. Immunohistochemical and histomorphometry.

Grant number: 10/00173-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2010
Effective date (End): April 30, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Roberta Okamoto
Grantee:Cassiano Costa Silva Pereira
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Hypertension is one of the most important public health problems worldwide. About 50% to 60% of hypertensive patients are unknown and, moreover, the wrong control of the disease contributes to this body, common in the dental office, to become even more dangerous. It is known that hypertension alters the pattern of regulation of calcium, which induces bone loss. Recent studies involving new family members of tumor necrosis factor (TNF), protein osteoprotegerin (OPG), RANK and its ligand RANKL associated with resorption and bone formation contributed to better understanding of the repair process. This study aims to evaluate the role of essential hypertension in bone metabolism during the wound healing process and analyze the influence of losartan, an antihypertensive drug-receptor antagonist of angiotensin II, through the expression of OPG protein, RANK, RANKL, osteocalcin, TRAP, VEGF and PECAM. This project will also lead the histomorphometric analysis of bone tissue formed. The groups will consist of Wistar-Kyoto (WKY) normotensive and spontaneously hypertensive rats (SHR) untreated and treated with losartan. By histomorphometric analysis and immunohistochemistry, we intend to relate the observed events (bone formation and expression of proteins) in each period after the completion of tooth extraction.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Cassiano Costa Silva. Análise do processo de reparo alveolar em ratos espontaneamente hipertensos (SHR) não tratados e tratados com Losartan: estudo imunoistoquímico e histomorfométrico. 2013. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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