|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||June 01, 2010|
|Effective date (End):||April 30, 2013|
|Field of knowledge:||Health Sciences - Dentistry - Oral and Maxillofacial Surgery|
|Principal researcher:||Roberta Okamoto|
|Grantee:||Cassiano Costa Silva Pereira|
|Home Institution:||Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil|
Hypertension is one of the most important public health problems worldwide. About 50% to 60% of hypertensive patients are unknown and, moreover, the wrong control of the disease contributes to this body, common in the dental office, to become even more dangerous. It is known that hypertension alters the pattern of regulation of calcium, which induces bone loss. Recent studies involving new family members of tumor necrosis factor (TNF), protein osteoprotegerin (OPG), RANK and its ligand RANKL associated with resorption and bone formation contributed to better understanding of the repair process. This study aims to evaluate the role of essential hypertension in bone metabolism during the wound healing process and analyze the influence of losartan, an antihypertensive drug-receptor antagonist of angiotensin II, through the expression of OPG protein, RANK, RANKL, osteocalcin, TRAP, VEGF and PECAM. This project will also lead the histomorphometric analysis of bone tissue formed. The groups will consist of Wistar-Kyoto (WKY) normotensive and spontaneously hypertensive rats (SHR) untreated and treated with losartan. By histomorphometric analysis and immunohistochemistry, we intend to relate the observed events (bone formation and expression of proteins) in each period after the completion of tooth extraction.