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Bone healing in crtical-size defects treated with either Bone Marrow Aspirate, Low-Level Laser Therapy or a combination of both therapies: a histologic and histometric study in rat calvaria.

Grant number: 10/04450-2
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Maria José Hitomi Nagata
Grantee:Carolina dos Santos Santinoni
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The purpose of this study is to histomorphometrically analyze the influence of Bone Marrow Aspirate (BMA), Low-Level Laser Therapy (LLLT) or their combination on bone healing in surgically created critical-size defects (CSD) in rat calvaria. 40 rats will be divided into 4 groups: Group C (control), Group BMA, Group LLLT and Group BMA/LLLT. A 5 mm diameter CSD will be created in the calvarium of each animal. In Group C, the defect will be filled by blood clot only. In Group BMA, the defect will be filled with BMA. In Group LLLT, the defect will receive laser irradiation (GaAIAs laser), will be filled with blood clot and then will be irradiated again. In Group BMA/LLLT, the defect will receive laser irradiation (GaAIAs laser), will be filled with BMA and then will be irradiated again. All animals will be euthanized at 30 days post-operatively. Histometric, using image analysis software, and histologic analyses will be performed. Amount of newly formed bone will be calculated as a percentage of the total area of the original defect. The data will be submitted to statistical analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAGATA, MARIA J. H.; SANTINONI, CAROLINA S.; POLA, NATALIA M.; DE CAMPOS, NATALIA; MESSORA, MICHEL R.; BOMFIM, SUELY R. M.; ERVOLINO, EDILSON; FUCINI, STEPHEN E.; FALEIROS, PAULA L.; GARCIA, VALDIR G.; et al. Bone marrow aspirate combined with low-level laser therapy: A new therapeutic approach to enhance bone healing. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 121, p. 6-14, . (10/04450-2, 10/18925-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTINONI, Carolina dos Santos. Cicatrização óssea de defeitos de tamanho crítico tratados com Aspirado de Medula Óssea, Laser em Baixa Intensidade ou a associação de ambas as terapias: estudo histológico e histométrico em calvárias de ratos. 2012. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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