Transformation of lignan (-)-grandisin by microorganisms and hepatic microsomes: an alternative to new drugs metabolism studies.

• Grant number: 10/12765-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2010
• End date: June 30, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Mônica Tallarico Pupo
• Grantee: Gisele Baraldi Messiano
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system, AP.BTA.TEM

Abstract

Biotransformation is the essential step to obtain information about the new drugs metabolism, and microorganism, in many cases, can be used in vitro assays. It is necessary the correct selection of the microorganism and the culture conditions, because the process optimization is essential to good results. Thus, we propose the biotransformation of a lignan with a potent trypanocidal activity, by different microorganisms and rat hepatic microsomes.