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Biotransformation of lapachol by filamentous fungi: proteomic analysis for identification to biotransformation route

Grant number: 14/01497-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Hamilton Cabral
Grantee:Luciana Barbosa Coitinho
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/12516-0 - Analysis of secretome from Phanerochaete chrysosporium and post-translational modifications of some proteins during the lapachol biotransformation process by mass spectrometry, BE.EP.DR


Nowadays, biotransformation has been highlighted as an important process to chemical transformations. This process is useful to obtain new compounds which are not easily generated by traditional chemical synthesis. Fungi biotransformations have know application in the pharmaceutical industry for drug development. This process is used to selective modification of natural and synthetic products also to obtain enantiomerically selectivity. Lapachol is a naphthoquinone extracted from Bignoniacea plants family that present a lot of interesting biological activities to pharmaceutical industry. A large number of studies of natural products biotransformation are reported in literature, but only a few are related with lapachol. Moreover, there are no studies about the biotransformation route of Lapachol by proteome technique. Thus the objective of this work is to study the lapachol biotransformation process by proteomics filamentous fungi, identifying biotransformed products and proposing the biotransformation route through identification of involved enzymes in the process. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COITINHO, LUCIANA BARBOSA; FUMAGALLI, FERNANDO; DA ROSA-GARZON, NATHALIA GONSALES; EMERY, FLAVIO DA SILVA; CABRAL, HAMILTON. Lapachol biotransformation by filamentous fungi yields bioactive quinone derivatives and lapachol-stimulated secondary metabolites. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v. 49, n. 5, p. 459-463, . (14/01497-9, 12/24703-8)
AMORIM, FERNANDA GOBBI; COITINHO, LUCIANA BARBOSA; DIAS, ANANDA TISSIANEL; FREITAS FRIQUES, ANDREIA GOMES; MONTEIRO, BRENNA LEPAUS; DIAS DE REZENDE, LUCAS CUNHA; COSTA PEREIRA, THIAGO DE MELO; CAMPAGNARO, BIANCA PRANDI; DE PAUW, EDWIN; VASQUEZ, ELISARDO CORRAL; et al. Identification of new bioactive peptides from Kefir milk through proteopeptidomics: Bioprospection of antihypertensive molecules. Food Chemistry, v. 282, p. 109-119, . (14/01497-9, 16/12516-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COITINHO, Luciana Barbosa. Biotransformation of lapachol by filamentous fungi - proteomic analysis to identification the biotransformation route. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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