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Studies on the biotransformation of pentacyclic triterpenes by filamentous fungi and evaluation of the antitumoral and trypanocide activities of the derivatives


The framing of this proposal in the Biota-FAPESP Program, BIOprospecTA subprogram, could prove to make a substantial contribution to the investigations which are currently underway among groups that make up the Network. In this project it is proposed to make available the extracts of culture media from the fungi and the derivatives isolated to be evaluated in the Network’s biotrials, as well as to make available the biotransformation trials for other bioactive substances provided by the other groups. The collaboration with the groups of the Network will provide greater chances of obtaining satisfactory results, given the availability of undertaking different trials such as the extracts and the isolated derivatives. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAPEL, CLARISSA S.; DE SOUZA, ANA C. D.; DE CARVALHO, TATIANE C.; DE SOUSA, JOAO P. B.; AMBROSIO, SERGIO R.; MARTINS, CARLOS H. G.; CUNHA, WILSON R.; GALAN, ROSARIO H.; FURTADO, NIEGE A. J. C. Biotransformation using Mucor rouxii for the production of oleanolic acid derivatives and their antimicrobial activity against oral pathogens. Journal of Industrial Microbiology & Biotechnology, v. 38, n. 9, p. 1493-1498, SEP 2011. Web of Science Citations: 15.
DE CARVALHO, TATIANE C.; POLIZELI, ALINE M.; TURATTI, IZABEL C. C.; SEVERIANO, MARCELA E.; DE CARVALHO, CARLOS E.; AMBROSIO, SERGIO R.; CROTTI, ANTONIO E. M.; DE FIGUEIREDO, UIR S.; VIEIRA, PAULO C.; FURTADO, NIEGE A. J. C. Screening of Filamentous Fungi to Identify Biocatalysts for Lupeol Biotransformation. Molecules, v. 15, n. 9, p. 6140-6151, SEP 2010. Web of Science Citations: 18.

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