Establishing heterologous expression and purification conditions of the human hypoxia-inducible factor 1, HIF-1, for crystallographic studies.

• Grant number: 10/13739-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: August 31, 2013
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Andre Luis Berteli Ambrosio
• Grantee: Angela Maria Fala
• Host Institution: Associação Brasileira de Tecnologia de Luz Síncrotron (ABTLuS). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated scholarship(s): 12/05997-0 - Structural studies of the complexes formed between the oxygen-dependent degradation domain (ODD) of HIF-1alpha and prolil-hydroxilases, BE.EP.MS

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FALA, ANGELA M.; OLIVEIRA, JULIANA F.; ADAMOSKI, DOUGLAS; ARICETTI, JULIANA A.; DIAS, MARILIA M.; DIAS, MARCIO V. B.; SFORCA, MAURCIO L.; LOPES-DE-OLIVEIRA, PAULO S.; ROCCO, SILVANA A.; CALDANA, CAMILA; et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha. SCIENTIFIC REPORTS, v. 5, AUG 3 2015. (12/14298-9, 10/13739-6, 14/04927-4, 14/20673-2, 14/15968-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FALA, Angela Maria. Heterologous expression and purification of the hypoxia-induced factor HIF-1 human aiming structural and biochemical studies and structural studies of prolyl-hydroxylases (PHDs) human, isoforms 1 and 3, in complex with inhibitors. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.