Functional and molecular characterization of estrogen related receptors (ERR)± in canine mammary neoplasms

• Grant number: 11/02400-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2011
• End date: September 30, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Maria Lucia Zaidan Dagli
• Grantee: Luciana Boffoni Gentile
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The development of veterinary medicine in the past 20-25 years has allowed a significant improvement in standard of life of pets. With the increase in lifespan of small animals, it is currently being observed an increased prevalence of cancers in dogs and cats. In addition, veterinarians are increasingly required to diagnose, treat and prevent cancer in small animals. Many of the tumors developed in animals, particularly dogs and cats, such as breast cancer, lymphoma, osteosarcoma, skin cancer and central nervous system resemble the neoplasms developed in humans, and ,therefore, recent reports inform that animal cancers are good models for understanding cancer in humans. The family of receptors related to Estrogen Receptor (ERRS) is composed of three members, ERR± (NR3B1 or) ERR² (or NR3B2) and ERR³ (NR3B3 or). Recent studies have indicated ERR± as a possible progonostic marker in human breast cancer. The purpose of this project is to study in breast tumors of dogs and cats, the gene expression of the three ERR family members (ERR±, ERR², ERR³). This project will also include in vitro studies with cells derived from breast epithelial tissue and the different types of tumors in order to elucidate the correlation between the expression patterns of ERR and tumor progression. Finally, the standardization of such methodological tools in the canine model study of cancer will allow more detailed study of the action of new anticancer agents and cancer chemoprevention, which may subsequently be applied to animals and man. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GENTILE, LUCIANA B.; NAGAMINE, MARCIA K.; BIONDI, LUIZ R.; SANCHES, DANIEL S.; TOYOTA, FABIO; GIOVANI, TATIANE M.; DE JESUS, ISIS P.; DA FONSECA, IVONE I. M.; QUEIROZ-HAZARBASSANOV, NICOLLE; DIAZ, BRUNO L.; et al. Establishment of primary mixed cell cultures from spontaneous canine mammary tumors: Characterization of classic and new cancer-associated molecules. PLoS One, v. 12, n. 9, SEP 25 2017. (11/02400-0)

BIONDI, LUIZ ROBERTO; TEDARDI, MARCELLO VANNUCCI; GENTILE, LUCIANA BOFFONI; COSTA CHAMAS, PATRICIA PEREIRA; ZAIDAN DAGLI, MARIA LUCIA. Quantification of Global DNA Methylation in Canine Mammary Gland Tumors via Immunostaining of 5-Methylcytosine: Histopathological and Clinical Correlations. FRONTIERS IN VETERINARY SCIENCE, v. 8, FEB 25 2021. (11/02400-0, 11/14177-4)