|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||June 01, 2011|
|Effective date (End):||May 31, 2014|
|Field of knowledge:||Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery|
|Principal Investigator:||José Jurandir Fagliari|
|Grantee:||Kalina Maria de Medeiros Gomes Simplício|
|Home Institution:||Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil|
Although Brazil has the highest goat milk production in the American continent, it contributes with only 141.000 milk tons/year, contrasting with countries like France with an annual goat milk production of 500.000 tons and where cheese manufactured from goat milk is held as a fine delicacy. A limiting factor to the dairy industry is the presence of diseases, especially mastitis, which when not treated becomes a serious problem with considerable economic losses. Staphylococcus aureus is the major ethiologic agent involved in goats mastitis, followed by Streptococcus agalactiae; both pathogens have been related to the occurrence of alimentary intoxications all around the world. Recent researches suggest that in the future acute phase proteins (APP) essays, highly sensible biomarkers of inflammation, will be used in the veterinary routine to evaluate the state of health of individuals and herds, optimize productive performance, monitor the efficacy of antibiotic therapies and detect subclinical diseases, such as subclinical mastitis. Despite the clinical value of APPs determinations in goat medicine, there is scarce available information in the literature. So the aim of this study was to determine the leucocyte count, serum biochemical profile, especially of acute phase proteins and immunoglobulins, of goats with experimentally induced mastitis by Staphylococcus aureus and Streptococcus agalactiae, as well as verify its importance as early biomarkers of mammary infection and identify the main APPs involved in the acute phase response.