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Functional characterization of the LIN28 protein in tumorigenesis of the central nervous system

Grant number: 11/51588-2
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Oswaldo Keith Okamoto
Grantee:Márcia Cristina Teixeira dos Santos
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):12/22950-8 - Functional characterization of RNA binding proteins Lin28 and Msi1 in neurogenesis, BE.EP.PD


Neoplastic stem cells have been identified in a variety of human cancers, in which they are associated with the initial steps of tumorigenesis. The tumor-initiating cell phenotype may result from genetic alterations affecting the expression of critical genes regulating typical stem cell process such as self-renewal and pluripotency. It is becoming apparent that RNA-binding proteins control the biogenesis of miRNA, affecting their activity and stability. LIN28 is an RNA binding protein that acts as repressor of miRNA processing and as a post-transcriptional regulatory factor for some mRNAs. LIN28 is ectopically expressed in some malignant tumors, but details of its molecular function remain to be clarified within the cancer context. In the present study, we propose to examine the subset of RNAs and proteins that specifically bind to LIN28 in human medulloblastoma cells, to clarify its relation with tumorigenesis in the central nervous system. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, MARCIA C. T.; TEGGE, ALLISON N.; CORREA, BRUNA R.; MAHESULA, SWETHA; KOHNKE, LUANA Q.; QIAO, MEI; FERREIRA, MARCO A. R.; KOKOVAY, ERZSEBET; PENALVA, LUIZ O. F.. miR-124,-128, and-137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells, v. 34, n. 1, p. 220-232, . (12/22950-8, 11/51588-2, 13/25483-4)
GONCALVES DA SILVA, PATRICIA BENITES; TEIXEIRA DOS SANTOS, MARCIA CRISTINA; RODINI, CAROLINA OLIVEIRA; KAID, CAROLINI; LEITE PEREIRA, MARCIA CRISTINA; FURUKAWA, GABRIELA; GIMENES DA CRUZ, DANIEL SANZIO; GOLDFEDER, MAURICIO BARBUGIANI; REILY ROCHA, CLARISSA RIBEIRO; ROSENBERG, CARLA; et al. High OCT4A levels drive tumorigenicity and metastatic potential of medulloblastoma cells. ONCOTARGET, v. 8, n. 12, p. 19192-19204, . (11/51588-2, 11/05534-8, 11/10001-9, 10/52686-5, 13/02983-1, 13/08028-1, 13/17566-7)
TEIXEIRA SANTOS, MARCIA CRISTINA; GONCALVES SILVA, PATRICIA BENITES; RODINI, CAROLINA OLIVEIRA; FURUKAWA, GABRIELA; MARCO ANTONIO, DAVID SANTOS; ZANOTTO-FILHO, ALFEU; MOREIRA, JOSE C. F.; OKAMOTO, OSWALDO KEITH. Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma. STEM CELLS AND DEVELOPMENT, v. 24, n. 22, p. 2700-2708, . (11/51588-2, 11/10001-9, 10/52686-5, 13/08028-1, 13/17566-7)

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