Evaluation of cytotoxic and antioxidant potential of Eleutherine bulbosa Miller (Iridaceae)

• Grant number: 11/22723-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2012
• End date: December 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Regildo Márcio Gonçalves da Silva
• Grantee: Caio Pismel Alves
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Eleutherine bulbosa belongs to Iridaceae family and includes 90 genus and about 1200 species. As the reported folk medicine activity of the species, it was described as a vermifuge, menstruation regulator, intestinal disorders pain reliever, abortive, and anti-fertility. Scientific research has shown its effectiveness as antifungal, purgative, anti-cancer, antimicrobial, and abortive. Based on this information the project has the aim to evaluate the cytotoxic activity from the ethanolic extract of Eleutherine bulbosa bulbs by in vitro murine melanoma culture (B16F10 Nex 2.1) assay and inhibition of inducing tumor by Agrobacterium tumefaciens in Solanum tuberosum discs. Also has the aim to evaluate the antioxidant activity of the same extract by using the assay of free radical scavenging activity by DPPH and the effect of iron chelation, furthermore performing the quantification of phenols, total flavonoids, and tannins present in the extract. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, REGILDO MARCIO GONCALVES; ALVES, CAIO PISMEL; BARBOSA, FERNANDO CESAR; SANTOS, HUGO HENRIQUE; ADAO, KAUE MENDONCA; GRANERO, FILIPE OLIVEIRA; FIGUEIREDO, CELIA CRISTINA MALAGUTI; FIGUEIREDO, CARLOS ROGERIO; NICOLAU-JUNIOR, NILSON; SILVA, LUCIANA PEREIRA. Antioxidant, antitumoral, antimetastatic effect and inhibition of collagenase enzyme activity of Eleutherine bulbosa (Dayak onion) extract: In vitro, in vivo and in silico approaches. Journal of Ethnopharmacology, v. 318, p. 11-pg., 2024-01-10. (11/22723-9)