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Fluoride retention in dental biofilm: role of bacterial calcium binding and in situ anticariogenic potential

Grant number: 11/23677-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2012
Effective date (End): June 30, 2012
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Livia Maria Andaló Tenuta
Grantee:Tarcísio Jorge Leitão de Oliveira
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Despite the decline in dental caries in the last decades, the disease remains severe in groups of individuals, for whom effective prevention measures should be researched. Thus, the study of fluoride (F) retention in dental biofilm and its role as an ion source to the biofilm fluid, where ion exchange between the tooth and biofilm occurs, could help to develop methods that increase F retention. F is retained in dental biofilm: 1 due to bridging to calcium ions (Ca) on bacterial surfaces or 2 as the mineral calcium fluoride. From these reservoirs, both Ca and F could be released to plaque fluid during a pH drop, to interfere with de/remineralization events, but this has not been explored. In a study in progress, supported by FAPESP, a series of experiments is being conducted to evaluate the kinetics of Ca and F binding to bacterial surface and their release as a function of time and pH. However, the clinical significance needs to be tested in conditions similar to the oral environment. As an expansion of the current studies, the role of Ca and F retained on bacterial surfaces or as calcium fluoride will be studied with an in situ caries model, to evaluate the potential of each of these reservoirs as a source of ions to biofilm fluid, to interfere with the dynamics of the caries process. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEITAO, TARCISIO JORGE; CURY, JAIME APARECIDO; ANDALO TENUTA, LIVIA MARIA. Kinetics of calcium binding to dental biofilm bacteria. PLoS One, v. 13, n. 1 JAN 31 2018. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Tarcísio Jorge Leitão de. Kinetics of calcium and fluoride binding to the surface of streptococci and the importance of these ions as mineral reservoirs in dental biofilm. 2012. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba.

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