In situ evaluation of anticariogenic action of dentifrice with low fluoride content and supplemented with phosphate

• Grant number: 07/03254-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2007
• End date: September 30, 2010
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Alberto Carlos Botazzo Delbem
• Grantee: Eliana Mitsue Takeshita
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The use of dentifrices with low fluoride (F) content have been a form to decrease the fluoride ingeston and, also, the dental fluorosis decrease. The aim of this study will be evaluated, in situ, the efficacy of dentifrices with low fluoride content supplemented with phosphate (P). 10 adult volunteers will use acrylic palatal appliances each containing four bovine enamel blocks. This study will be performed in 3 phases during 14 days and a interval of 7 days between the phases. The enamel blocks will be polish and selected through surface microhardness (SMH). The volunteers will drip on the enamel blocks a solution of 20% sucrose and perform the treatment with dentifrices containing 500µgF/g and 1% of a phosphate salt, placebo (without F e P) and Crest® (1100µgF/g). After each phase, the percentage change of SMH, mineral loss (deltaZ) and F, calcium and phosphorus content in enamel will be calculated. The dental biofilm will be collected to perform the biochemical analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKESHITA, ELIANA M.; DANELON, MARCELLE; CASTRO, LUCIENE P.; CUNHA, ROBSON F.; DELBEM, ALBERTO C. B.. Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study. Caries Research, v. 50, n. 6, p. 571-578, 2016. (07/03660-0, 07/03254-2)

TAKESHITA, ELIANA M.; DANELON, MARCELLE; CASTRO, LUCIENE P.; SASSAKI, KIKUE T.; DELBEM, ALBERTO C. B.. Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ. Caries Research, v. 49, n. 4, p. 394-400, 2015. (07/03660-0, 07/03254-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TAKESHITA, Eliana Mitsue. Avaliação da ação do trimetafosfato sobre o biofilme dentário, desmineralização e remineralização do esmalte: estudos in vitro e in situ. 2010. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.