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Effect of a calcium prerinse on the anticaries efficacy of fluoridated solution: in situ study

Grant number: 14/00799-1
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Livia Maria Andaló Tenuta
Grantee:João Gabriel Silva Souza
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


The use of a calcium prerinse before a fluoride rins has been shown to significantly increase fluoride concentration in saliva and dental biofilm. However, the anticaries effect of this combination is yet to be confirmed experimentally. Therefore, the iam of this study is to test the potential of a calcium prerinse, followed by a fluoride rinse, to inhibit enamel demineralization and enhance enamel remineralization, using an in situ model presenting dose-response to fluoride solutions. In a double blind, crossover study conducted in 4 phases of 14 days, 18 volunteers will use palatal appliances containing bovine enamel blocks (4 sound and 4 with artificial caries lesions). A 20% sucrose solution will be dropped onto the blocks either 8 (sound) or 3 (carious) times per day. Treatments will be: placebo prerinse and rinse; placebo prerinse followed by a 250 ppm F rinse; placebo prerinse followed by a 1000 ppm F rinse; and experimental group using a calcium prerinse (150 mM Ca), followed by a 250 ppm F rinse. After 14 days, biofilm formed and the enamel blocks will be collected for the analysis of mineral ion concentrations in the fluid and solids, and change in mineral content, respectively. Groups will be compared statistically using appropriate tests. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, JOAO GABRIEL S.; ANDALO TENUTA, LIVIA MARIA; DEL BEL CURY, ALTAIR ANTONINHA; NOBREGA, DIEGO FIGUEIREDO; BUDIN, RENAN R.; DE QUEIROZ, MATEUS X.; VOGEL, GERALD L.; CURY, JAIME A.. Calcium Prerinse before Fluoride Rinse Reduces Enamel Demineralization: An in situ Caries Study. Caries Research, v. 50, n. 4, p. 372-377, . (14/00799-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, João Gabriel Silva. Effect of calcium prerinse on the enhancement of fluoride mouthrinse on the inhibition of enamel demineralization. 2016. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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