| Grant number: | 12/04516-9 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | September 01, 2012 |
| End date: | August 31, 2013 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery |
| Principal Investigator: | Ana Liz Garcia Alves |
| Grantee: | Caio Nunes de Barros |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract The platelet gel has been used as a sealant to control small bleedings and to induce the adherence of tissues. This kind of gel is mainly used to help in situations where the tissue repair capacity is limited, which is the case of chondral injuries. This biomaterial is indicated in the construction of scaffolds, required in the maintenance of several cell types, due to its ability to stimulate migration, differentiation, and cell proliferation. The platelet gel is also rich in growth factors and is widely used in the treatment of articular cartilage defects. However, despite knowledge about the advantages of this biomaterial and the domain of techniques of using it, the durability of platelet gel at the site of chondral injury is still discussed. Knowing the importance of this fact for the quality and efficiency of treatments that use platelet gel, this study aims to examine the durability and efficacy of treatments that use platelet gel through in vitro and in vivo studies. Thus, the platelet gel previously prepared from platelet-rich plasma obtained from healthy sheep will keep in culture plates (in vivo study) in the first step. In a second step, the gel will be implanted singly, by arthrotomy, on chondral defects induced in the articular surface of the lateral femoral trochlea of eight animals (in vivo study). In the in vitro study, will be measured the gel durability through the form maintenance and the consistency on the culture plates. The in vivo study will measure the durability and the scaffold (gel) interaction with the chondral tissue in the induced chondral defects in sheep.(AU) | |
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