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Bioinformatics applied to systems biology for regulatory factors identification of the sucrose accumulation in sugarcane stalk

Grant number: 12/12521-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2012
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Carlos Alberto Labate
Grantee:Fabrício Edgar de Moraes
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:08/56100-5 - Metabolomics of sugarcane and discovery of new hydrolytic enzymes for biofuel production, AP.BIOEN.TEM


Sugarcane (Saccharum spp.) is one of the most important cultivated grasses of the world and Brazil is the largest producer, which has as its main representative the São Paulo state that concentrating more than half the area for this crop. Thus, it is necessary a high understanding of the mechanisms that regulate the sucrose accumulation in this plant. The genetic mechanisms that control sugarcane sucrose accumulation have been studied at various levels, such as gene identification and localization, identification of quantitative trait locus controlling, transcriptome, proteome, characterization and metabolites identification. With all these studies is evident the necessity for a holistic approach to global understanding of the plant during the sucrose accumulation. Thus, this work aims to characterize metabolites and proteins during plant development and sucrose accumulation, using bioinformatics to link these results by Bayesian networks in a systems biology approach. Therefore, it will be possible to create a gene regulation network, identification of new gene functions, pathways and phenotypes related to the sugarcane sucrose accumulation. All information generated in this project will be integrated into SUCEST-FUN ( servers, allowing users to a crosslink between the data from transcriptomics, metabolomics, proteomics, molecular markers (such as E-QTLs and QTLs ) or any other service available on the server.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUDZINSKI, ILARA GABRIELA FRASSON; DE MORAES, FABRICIO EDGAR; CATALDI, THAIS REGIANI; FRANCESCHINI, LIVIA MARIA; LABATE, CARLOS ALBERTO. Network Analyses and Data Integration of Proteomics and Metabolomics From Leaves of Two Contrasting Varieties of Sugarcane in Response to Drought. FRONTIERS IN PLANT SCIENCE, v. 10, . (12/22227-4, 12/12521-2)
BOARETTO, LUIS FELIPE; VENEZIANO LABATE, MONICA TERESA; FRANCESCHINI, LIVIA MARIA; CATALDI, THAIS REGIANI; BUDZINSKI, ILARA GABRIELA F.; DE MORAES, FABRICIO EDGAR; LABATE, CARLOS ALBERTO. Proteomics Reveals an Increase in the Abundance of Glycolytic and Ethanolic Fermentation Enzymes in Developing Sugarcane Culms During Sucrose Accumulation. FRONTIERS IN PLANT SCIENCE, v. 12, . (12/22227-4, 08/56100-5, 12/12521-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MORAES, Fabrício Edgar de. Bioinformatics applied to systems biology for regulatory factors identification of the sucrose accumulation in sugarcane stalk. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Matemática e Estatística (IME/SBI) São Paulo.

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