Assessment of dissolution time of coating and disintegration in magnetic tablet by Biosuceptometria AC

• Grant number: 12/13726-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2012
• End date: December 31, 2013
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: José Ricardo de Arruda Miranda
• Grantee: Deivid William Pires
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 10/07639-9 - Gastrointestinal motility: clinical investigations, physiopathology and biopharmaceutical, AP.TEM

Abstract

When administering a drug to be considered as factors such as the pharmaceutical form appropriate route of administration and the more efficiently it will be well accepted by the patient. Solid dosage forms (FFS), such as tablets, represent the main choice because they are easy to prepare, store, transport, and are well tolerated by patients. However, the absorption of drugs administered depends on tablet disintegration process, ie a time-dependent process that occurs under the action of a disintegrant which promotes fragmentation of the particulate dosage form capable of being dissolved and absorbed. For an effective release of the asset, each of the criteria related to the choice of formulation excipients and coating type must be considered. The coating polymer is used to improve the drug stability, mask the taste or promote the site-specific release in accordance with the change in pH. The technique considered the "gold standard" for monitoring FFS in the gastrointestinal tract of man is scintigraphy, however, alternative methods based on detection of the magnetic field are worth mentioning. The technique Biosusceptometria Alternating Current (BAC) has evolved, with the advantage of being non-invasive and free of ionizing radiation. BAC uses inductors for recording the temporal variation of magnetic flux from the response of a magnetic material ingested by applying an alternating magnetic field in a biological environment. The aim of this study is to employ the BAC to evaluate in vitro the influence of three different polymer coating pharmacy technical various parameters and in the process of disintegration of tablets.(AU)