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Instrumentation and applications by biosusceptometry alternating current: nanoparticles distribution studies, motility and quality control of solid dosage forms

Abstract

The use of noninvasive techniques, inexpensive and harmless to the individual provides a great challenge for the study of the gastrointestinal tract and other systems. Biomagnetic methods such as AC Biosusceptometry provide these advantages and include the possibility of expanding to new studies, instrumental arrangements and other biological models. The consolidation of this technique in recent years has enabled the extension of these studies to reach the pharmaceutical field, for the study of diseases in animal models, the development of new systems and more recently, detection and characterization of magnetic nanoparticles in biological systems. These approaches, unpublished pictures of nanostructured magnetic systems in the gastrointestinal tract, circulation, kidneys, liver and brain, provided by the BAC is another important aspect that we want to explore. In summary, this project envisions a multidisciplinary proposal that relates instrumentation, biophysics, pharmaceutical technology and detection and biodistribution of nanoparticles, contributing to support physiological and clinical parameters, in order to implement consistently the biomagnetic technique in different fields of study of biological systems. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Técnica permite monitorar nanopartículas magnéticas em organismos vivos 
Technique permits the monitoring of magnetic nanoparticles in living organisms 
Una técnica permite el monitoreo de nanopartículas magnéticas en organismos vivos 

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PROSPERO, ANDRE G.; FIDELIS-DE-OLIVEIRA, PATRICIA; SOARES, GUILHERME A.; MIRANDA, MILENA F.; PINTO, LEONARDO A.; DOS SANTOS, DANIELA C.; SILVA, VANESSA DOS S.; ZUFELATO, NICHOLAS; BAKUZIS, ANDRIS F.; MIRANDA, JOSE R. A. AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats. Nanomedicine, v. 15, n. 5, p. 509-525, FEB 2020. Web of Science Citations: 0.
CALABRESI, MARCOS F. F.; TANIMOTO, ALEXANDRE; PROSPERO, ANDRE G.; MELLO, FABIO P. F.; SOARES, GUILHERME; DI STASI, LUIZ C.; MIRANDA, JOSE R. A. Changes in colonic contractility in response to inflammatory bowel disease: Long-term assessment in a model of TNBS-induced inflammation in rats. Life Sciences, v. 236, NOV 1 2019. Web of Science Citations: 0.
SOARES, GUILHERME A.; PROSPERO, ANDRE G.; CALABRESI, MARCOS F.; RODRIGUES, DIEGO S.; SIMOES, LUIS G.; QUINI, CAIO C.; MATOS, RONALDO R.; PINTO, LEONARDO A.; SOUSA-JUNIOR, AILTON A.; BAKUZIS, ANDRIS F.; MANCERA, PAULO A.; MIRANDA, JOSE R. A. Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging. IEEE Transactions on Nanobioscience, v. 18, n. 3, p. 456-462, JUL 2019. Web of Science Citations: 0.
MATOS, JULIANA FERNANDES; AMERICO, MADILEINE FRANCELY; SINZATO, YURI KAREN; VOLPATO, GUSTAVO TADEU; CORA, LUCIANA APARECIDA; FREITAS CALABRESI, MARCOS FELIPE; OLIVEIRA, RICARDO BRANDT; DAMASCENO, DEBORA CRISTINA; ARRUDA MIRANDA, JOSE RICARDO. Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats. WORLD JOURNAL OF GASTROENTEROLOGY, v. 22, n. 25, p. 5761-5768, JUL 7 2016. Web of Science Citations: 7.

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