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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging

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Soares, Guilherme A. [1] ; Prospero, Andre G. [1] ; Calabresi, Marcos F. [1] ; Rodrigues, Diego S. [2] ; Simoes, Luis G. [1] ; Quini, Caio C. [1] ; Matos, Ronaldo R. [1] ; Pinto, Leonardo A. [1] ; Sousa-Junior, Ailton A. [3] ; Bakuzis, Andris F. [3] ; Mancera, Paulo A. [4] ; Miranda, Jose R. A. [1]
Total Authors: 12
[1] UNESP Sao Paulo State Univ, Lab Biomagnetismo, Dept Fis & Biofis, BR-18618689 Botucatu, SP - Brazil
[2] UNIFAL MG Univ Fed Alfenas MG, Dept Fis, ICEx, BR-37133840 Alfenas, MG - Brazil
[3] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go - Brazil
[4] UNESP Sao Paulo State Univ, Dept Bioestat, IBB, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: IEEE Transactions on Nanobioscience; v. 18, n. 3, p. 456-462, JUL 2019.
Web of Science Citations: 0

In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP. (AU)

FAPESP's process: 15/14923-9 - Instrumentation and applications by biosusceptometry alternating current: nanoparticles distribution studies, motility and quality control of solid dosage forms
Grantee:José Ricardo de Arruda Miranda
Support type: Regular Research Grants