| Full text | |
| Author(s): Show less - |
Soares, Guilherme A.
[1]
;
Prospero, Andre G.
[1]
;
Calabresi, Marcos F.
[1]
;
Rodrigues, Diego S.
[2]
;
Simoes, Luis G.
[1]
;
Quini, Caio C.
[1]
;
Matos, Ronaldo R.
[1]
;
Pinto, Leonardo A.
[1]
;
Sousa-Junior, Ailton A.
[3]
;
Bakuzis, Andris F.
[3]
;
Mancera, Paulo A.
[4]
;
Miranda, Jose R. A.
[1]
Total Authors: 12
|
| Affiliation: | [1] UNESP Sao Paulo State Univ, Lab Biomagnetismo, Dept Fis & Biofis, BR-18618689 Botucatu, SP - Brazil
[2] UNIFAL MG Univ Fed Alfenas MG, Dept Fis, ICEx, BR-37133840 Alfenas, MG - Brazil
[3] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go - Brazil
[4] UNESP Sao Paulo State Univ, Dept Bioestat, IBB, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | IEEE Transactions on Nanobioscience; v. 18, n. 3, p. 456-462, JUL 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP. (AU) | |
| FAPESP's process: | 15/14923-9 - Instrumentation and applications by biosusceptometry alternating current: nanoparticles distribution studies, motility and quality control of solid dosage forms |
| Grantee: | José Ricardo de Arruda Miranda |
| Support Opportunities: | Regular Research Grants |