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Mapping of the distribution of magnetic nanoparticles in a model of hepatocellular carcinoma through magnetic images

Grant number: 19/11277-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2021
Field of knowledge:Biological Sciences - Biophysics - Biophysics of Processes and Systems
Principal Investigator:José Ricardo de Arruda Miranda
Grantee:Gabriele Martins Pereira
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Magnetic nanoparticles (NPMs) are nanometer-scale materials that have have been widely studied today due to their magnetic properties. The field of nanotechnology is promising since this science has demonstrated numerous applications, one of them being medicine, as a controlled delivery of drugs and alternative use as a contrast agent in resonance tests magnetic resonance imaging (MRI). Hepatocellular carcinoma (HCC) is the fourth type of cancer that most kills people in the world, so it demands to be studied. It is still necessary to know better some parameters about the liver with this tumor, to be able to find and possible tools for a more efficient early diagnosis. The Alternating Current Biosusceptometry (ACB) has shown a good performance in the detection of NPMs exhibiting their biodistribution, for example. The use of BAC in detection of NPMs in rodent livers (healthy and with CHC) is a proposal that can contribute intensively to a better evaluation of carcinoma. In addition to elucidating the pharmacokinetics and interaction of NPMs with hepatic different conditions, which may be of great importance for possible applications in the nanomedicine. The purpose of this project is to develop a evaluation of in vivo pharmacokinetic and physiological parameters in animals in hepatocellular carcinogenesis, through dynamic images, using Biosusceptometry A.C.