This project is integrant of chemical and pharmacological validation of extracts and active compounds of copaifera speci

• Grant number: 12/15092-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2012
• End date: September 30, 2014
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Claudia Helena Pellizzon
• Grantee: Lucas Fernando Sérgio Gushiken
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM

Abstract

The skin is a complex system and essential to the integrity of the body and made a highly differentiated protective barrier. The discontinuity in this system promotes a scar. After injury total epithelial renewal depends on several intermediate stages and overlapping, such as inflammation (exudative phase), reconstruction (proliferative phase), epithelialization (regenerative phase), and maturation. The phase's evolution depends on cell migration, vasoconstriction, angiogenesis, granulation tissue, and deposit of extracellular matrix. This project aims to compare the effect on wound healing of hydroalcoholic and copaiba oil in different concentrations and different moments on day 3rd, 7 the, and 21 th after skin lesion. Therefore, the wound healing was analyzed by macroscopic and microscopic parameters and the mechanism of action by hydroalcoholic and copaiba oil. We will analyze the cell area, local fibrosis and in terms of immunohistochemical for cell proliferation factor (PCNA), epidermal growth factor (EGF), and expression of cyclooxygenase-2 (COX-2), and examined toxicity for liver and kidney pathways during the experimental period.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SERGIO GUSHIKEN, LUCAS FERNANDO; HUSSNI, CARLOS ALBERTO; BASTOS, JAIRO KENUPP; ROZZA, ARIANE LEITE; BESERRA, FERNANDO PEREIRA; VIEIRA, ANA JULIA; PADOVANI, CARLOS ROBERTO; LEMOS, MARIVANE; POLIZELLO JUNIOR, MAURILIO; MANGABEIRA DA SILVA, JONAS JOAQUIM; et al. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-based Complementary and Alternative Medicine, 2017. (11/13630-7, 12/15092-5, 14/23684-5)

SERGIO GUSHIKEN, LUCAS FERNANDO; HUSSNI, CARLOS ALBERTO; BASTOS, JAIRO KENUPP; ROZZA, ARIANE LEITE; BESERRA, FERNANDO PEREIRA; VIEIRA, ANA JULIA; PADOVANI, CARLOS ROBERTO; LEMOS, MARIVANE; POLIZELLO JUNIOR, MAURILIO; MANGABEIRA DA SILVA, JONAS JOAQUIM; et al. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 16-pg., 2017-01-01. (11/13630-7, 14/23684-5, 12/15092-5)