Study of the role of the immunoregulatory molecule HLA-G in Multiple sclerosis and Experimental autoimmune encephalomyelitis

• Grant number: 12/09879-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2012
• End date: February 29, 2016
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Adriel dos Santos Moraes
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The HLA-G molecules, expressed in cells or soluble, are described as critical for the induction of immunological tolerance. These molecules are expressed in many cell types and are involved in the induction of regulatory T lymphocytes. In this study we intend to analyze the regulatory function of HLA-G both in patients with multiple sclerosis (MS) treated with immunomodulators, such as the experimental model of this disease experimental autoimmune encephalitis (EAE). In MS, we want to study the HLA-G expressed plasmacytoid dendritic cells present in cerebrospinal fluid (CSF) at different stages of the disease, and peripheral blood in the process of induction of regulatory T lymphocytes. In EAE, we attempted to verify if the HLA-G are expressed in neurons at different stages of the disease induced in Lewis rats. If so, we intend to investigate how these molecules act in the interaction with T lymphocytes encephalitogen.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORAES, ADRIEL S.; BOLDRINI, VINICIUS O.; DIONETE, ALLINY C.; ANDRADE, MARILIA D.; LONGHINI, ANA LEDA F.; SANTOS, IRENE; LIMA, AMANDA D. R.; SILVA, VERONICA A. P. G.; DIAS CARNEIRO, RAFAEL P. C.; QUINTILIANO, RAPHAEL P. S.; et al. Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients - Brief Research Report. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, JUL 26 2021. (12/09879-2, 14/26431-0, 13/00837-8)

MORAES, ADRIEL S.; PAULA, ROSEMEIRE F. O.; PRADELLA, FERNANDO; SANTOS, MARIANA P. A.; OLIVEIRA, ELAINE C.; VON GLEHN, FELIPE; CAMILO, DANIELA S.; CERAGIOLI, HELDER; PETERLEVITZ, ALFREDO; BARANAUSKAS, VITOR; et al. The Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitis. CNS Neuroscience & Therapeutics, v. 19, n. 9, p. 682-687, SEP 2013. (12/04565-0, 11/18728-5, 11/15175-5, 11/15639-1, 12/09879-2, 12/01408-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAES, Adriel dos Santos. Study of regulatory molecules in multiple sclerosis and experimental autoimmune encephalomyelitis. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.