Influence of gut microbiota on NKT cells profile in an experimental model of colitis

• Grant number: 12/16794-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2012
• End date: March 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Cristhiane Favero de Aguiar
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches, AP.TEM
• Associated scholarship(s): 14/10828-9 - Function of intestinal lamina propria NKT cells, BE.EP.DR

Abstract

Inflammatory bowel diseases are disorders that affect millions of people worldwide. The inflammatory process in these diseases involves innate and adaptive immunity and also an influence of gut microbiota. NKT cells are a distinct subtype of T lymphocytes which play a role in intestinal mucosal immunity in experimental models of colitis. Studies regarding the role of NKT cells, gut microbiota and the inflammatory process in colitis are still scarce. Therefore, our project aims to relate the influence of gut microbiota in the profile of NKT cells during colitis and how such change may affect inflammation. Thus, we will use an experimental model of DSS-induced colitis to assess the role of NKT cells in colitis and the influence of changing gut microbiota in the profile of these cells. We will analyze the profile of cytokines and chemokines involved in this model, the phenotype of NKT cells through flow cytometry, histology of intestinal tissue and changes in microbiota. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTOLDI, ANGELA; DE AGUIAR, CRISTHIANE FAVERO; MORAES-VIEIRA, PEDRO MANOEL; SARAIVA CAMARA, NIELS OLSEN. They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa. CURRENT PROTEIN & PEPTIDE SCIENCE, v. 16, n. 7, p. 655-671, 2015. (14/10828-9, 12/02270-2, 12/16794-3, 14/02218-6, 11/15682-4)

DE AGUIAR, CRISTHIANE FAVERO; CASTOLDI, ANGELA; AMANO, MARIANE T.; IGNACIO, ALINE; TERRA, FERNANDA FERNANDES; CRUZ, MARIO; FELIZARDO, RAPHAEL J. F.; BRAGA, TARCIO TEODORO; DAVANZO, GUSTAVO GASTAO; GAMBARINI, VICTOR; et al. Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells. INFLAMMATORY BOWEL DISEASES, v. 26, n. 5, p. 697-708, MAY 2020. (12/16794-3, 12/02270-2, 17/12848-5)

DE AGUIAR, CRISTHIANE FAVERO; CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; IGNACIO, ALINE; DA CUNHA, FLAVIA FRANCO; FERREIRA FELIZARDO, RAPHAEL JOSE; BASSI, ENIO JOSE; SARAIVA CAMARA, NIELS OLSEN; DE ALMEIDA, DANILO CANDIDO. Mesenchymal stromal cells modulate gut inflammation in experimental colitis. INFLAMMOPHARMACOLOGY, v. 26, n. 1, p. 251-260, FEB 2018. (13/25327-2, 12/02270-2, 12/16794-3)

AGUIAR, CRISTHIANE FAVERO; NAFFAH-DE-SOUZA, CRISTIANE; CASTOLDI, ANGELA; CORREA-COSTA, MATHEUS; BRAGA, TARCIO T.; NAKA, ERIKA L.; AMANO, MARIANE T.; ABATE, DEBORA T. R. S.; HIYANE, MEIRE I.; CENEDEZE, MARCOS A.; et al. Administration of alpha-Galactosylceramide Improves Adenine-Induced Renal Injury. Molecular Medicine, v. 21, p. 553-562, 2015. (07/07139-3, 12/02270-2, 12/16794-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AGUIAR, Cristhiane Favero de. Role of NKT cells in intestinal homeostasis and inflammation.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.