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Different periods of time for salivary remineralization on initial erosion lesion: an in situ study

Grant number: 12/20014-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal researcher:Daniela Rios Honório
Grantee:Luísa Belluco Guerrini
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


The protective potential of saliva has been described in the literature as an important factor that influences the pathogenesis of dental erosion. Although extremely important in the process of initial erosion lesion remineralization, there is no standardization of the time necessary to achieve remineralization of softened surface layer, between the erosive challenges in situ studies. The aim of this in situ study is to evaluate the remineralizing effect of saliva on bovine enamel previously subjected to demineralization in vitro (initial erosion lesions). The factor under study is the period of time needed for in situ remineralizations (15 minutes, 30 minutes, 1 hour, and 2 hours). The study will be performed in situ, with a duration of 2 hours. The sample number will be 10 to 20 volunteers (to be determined). Prior to the use of the palatal device, enamel blocks will be demineralized in vitro (0.05 M citric acid for 15 min) and the surface microhardness of the initial erosion lesion will be determined. During the 2 hours of in situ remineralizations, the volunteers will remove the appliance from the mouth for the removal of specimens and immediate reading of microhardness after remineralization, which will be performed consecutively on the same specimen, in the studied periods of time (15 min, 30 min, 1 h, and 2 h). Enamel changes will be analyzed by comparing hardness after demineralization (in vitro) with hardness after remineralization (in situ). The results will be statistically analyzed considering p <0.05.(AU)

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