Advanced search
Start date

Remineralizing effect of saliva on initial erosive lesion, using mandibular intraoral appliance

Grant number: 14/00102-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2014
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal researcher:Daniela Rios Honório
Grantee:Poliana Pacifico Val
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


The protective potential of saliva has been described in the literature as an important factor, which influences the pathogenesis of dental erosion. Although extremely important for the remineralization process of initial erosive lesion, there is not standardization of in situ studies, regarding the time between erosive challenges simulating the remineralization of softened erosive surface layer. The aim of this study is to evaluate the remineralizing in situ effect of saliva (in which the volunteers wear mandibular appliance) on initial enamel erosive lesion resulted from in vitro erosive demineralization. The study factor is in situ remineralization on different intervals (30 min, 1h, 2h, 12h). The in situ phase will have the duration of 12 hours and a sample size will be 12 volunteers. The enamel blocks will be demineralized in vitro (citric acid 0,05 M for 2 min) and the surface hardness (n=48) will be evaluated before the use of the mandibular oral appliance by the volunteers (four specimens for each appliance per group, for each volunteer). During the 12 hours of the in situ remineralization the volunteers will be requested to use the oral appliance and the blocks will be removed for immediate reading of hardness after remineralization, which will be held consecutively in the same block, on the intervals of salivary remineralization (30 min, 1h, 2h, 12h). The response variable will be changes of enamel hardness (comparison of hardness after demineralization (in vitro) with hardness after remineralization (in situ). The results will be subjected to appropriate statistical analysis considering p<0.05.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IONTA, FRANCINY QUEROBIM; BARROS DE ALENCAR, CATARINA RIBEIRO; DOS SANTOS, NATALIA MELLO; PORTALUPPE BERGANTIN, BIANCA TOZI; VAL, POLIANA PACIFICO; HONORIO, HEITOR MARQUES; DE OLIVEIRA, THAIS MARCHINI; RIOS, DANIELA. Effect of palm oil alone or associated to stannous solution on enamel erosive-abrasive wear: A randomized in situ/ex vivo study. ARCHIVES OF ORAL BIOLOGY, v. 95, p. 68-73, NOV 2018. Web of Science Citations: 0.
IONTA, FRANCINY QUEROBIM; BARROS DE ALENCAR, CATARINA RIBEIRO; VAL, POLIANA PACIFICO; BOTEON, ANA PAULA; JORDAO, MAISA CAMILLO; HONORIO, HEITOR MARQUES; RABELO BUZALAF, MARILIA AFONSO; RIOS, DANIELA. Effect of vegetable oils applied over acquired enamel pellicle on initial erosion. Journal of Applied Oral Science, v. 25, n. 4, p. 420-426, JUL-AUG 2017. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: