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Role of MuRF1 and MuRF2 in skeletal muscle myogenic cell differentiation

Grant number: 12/13315-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): July 31, 2016
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Anselmo Sigari Moriscot
Grantee:João Guilherme de Oliveira Silvestre
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Proteasome dependent proteolysis is a key process in skeletal muscle atrophy. Nonetheless the role of proteasome dependent proteolysis in other aspects of skeletal muscle remodeling such as fiber type specification is not well known. Ongoing experiments out of another study from our group show that MuRF1/MuRF2 knock out mice fail to regenerate properly, by mechanisms involving deficient differentiation. In addition we have evidence that this deficient regeneration involves presence of white adipocytes, raising the possibility that MuRFs are involved in maintenance of skeletal muscle cell phenotype. The main aim of this study is to understand the role of MuRFs upon skeletal muscle cell differentiation. Also we aim to determine whether MurFs are important to maintaining skeletal muscle cell identity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS, G. V.; CRUZ, A.; SILVA, W. J.; ROZANSKI, A.; BAPTISTA, I. L.; SILVESTRE, J. G.; MORISCOT, A. S.. Thyroid hormone upregulates MDM2 in rat type I fibre: Implications for skeletal muscle mass regulation. ACTA PHYSIOLOGICA, v. 222, n. 4, . (12/13071-0, 17/09398-8, 12/13315-7, 12/22488-2, 15/04090-0)
J.G. SILVESTRE; I.L. BAPTISTA; W.J. SILVA; A. CRUZ; M.T. SILVA; E.H. MIYABARA; S. LABEIT; A.S. MORISCOT. The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts. Brazilian Journal of Medical and Biological Research, v. 52, n. 9, . (16/12941-2, 15/04090-0, 12/13315-7)
SILVESTRE, JOAO GUILHERME; BAPTISTA, IGOR LUCHINI; SILVA, WILLIAM JOSE; MORISCOT, ANSELMO SIGARI. The E3 Ligases MuRF1 and MuRF2 Play a Key Role in Skeletal Muscle Fibroblast Functional Capacity. FASEB JOURNAL, v. 30, p. 2-pg., . (12/13315-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVESTRE, João Guilherme de Oliveira. Role of MuRF1 and MuRF2 on functional and structural aspects of myoblasts and fibroblasts skeletal muscle cells.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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