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Effect of passive smoking in mucociliary clearance and the autonomic nervous system

Grant number: 13/03147-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): January 31, 2015
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ercy Mara Cipulo Ramos
Grantee:Ana Paula Coelho Figueira Freire
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


Many of the losses associated with smoking habit can be extended to passive smokers. Studies on passive smoking and its effects on mucociliary transport in human beings are still unclear in related literature. Objectives: To investigate the effect of passive smoking on mucociliary transport and in the autonomic nervous system of passive smokers and to investigate possible correlations between these variables. Methods: The sample comprised of 102 individuals, will be divided into three groups: passive smokers, active smokers and a control group with no history of tobacco smoke exposure. The protocol will be performed in two days. The first day will consist of specific questionnaires to each group and spirometry. In a second step it will be performed the avaliation of the heart rate variability (HRV), measurement of vital signs and carbon monoxide (CO) in expired air. Then it will be evaluate the mucociliary transportability (TMC) of all subjects .Statistical Analysis: Data will be analyzed following Graphpad Prism ® statistics program. Data normality will be assessed by the Shapiro-Wilk test. Data will be expressed as mean ± standard deviation, except for variables with non-normal distribution, which will be described as average. For inter-group analysis unpaired t test or Mann-Whitney test will be used, depending on data normality. For intra-group assessment, analysis of variance for repeated measures ANOVA followed by Tukey test will be used in the three phases. Correlations between HRV data and TTS will be evaluated by using the Pearson or Spearman coefficients, depending on the normal data distribution. The significance level to be utilized will be p <0.05.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FREIRE, Ana Paula Coelho Figueira. Efeitos do tabagismo passivo no tranporte mucociliar e sistema nervoso autônomo de adultos. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

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