"Development of nanoparticles containing gallic acid and methodology to real time monitoring the controlled release of the drug".

• Grant number: 13/05448-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2013
• End date: August 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Hideko Yamanaka
• Grantee: Mariele Mucio Pedroso
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, is recognized as a serious public health problem in Brazil and worldwide. The availability of drugs for Chagas' disease is extremely restrict and therefore it is estimated that only 1% of infected individuals receiving some type of treatment. Many natural and synthetic products have being evaluated against Trypanosoma cruzi, such as the synthetic derivative of gallic acid, tetradecil gallate, which is used in this project. To solve the problems of the compound solubility in water and consequently improve its bioavailability, lipid carriers will be used in controlled systems, to obtain release rates and appropriate activity of the drug in the body. In this context, this project aims at the synthesis and characterization of lipid nanocarriers to encapsulate the compound galato de tetradecila. Furthermore, will be performed continuous electrochemical in vitro monitoring of the kinetics of drug release from therapeutic nanoparticles. For this purpose an electrochemical sensor is used as analytical method for the detection of low levels of analyte concentration in solution. The electrochemical protocol for real-time monitoring will be able to evaluate the release profile an essential factor to establish therapeutic index of the drug and the potential clinical appliance.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEDROSO, MARIELE MUCIO; FOGUEL, MARCOS VINICIUS; SIQUEIRA SILVA, DULCE HELENA; TABOADA SOTOMAYOR, MARIA DEL PILAR; YAMANAKA, HIDEKO. Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer. SENSORS AND ACTUATORS B-CHEMICAL, v. 253, p. 180-186, DEC 2017. (14/25264-3, 13/07600-3, 13/05448-0)