Development of electroanalytical methodology for quantification of gallic acid derivatives

• Grant number: 13/24600-7
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): April 01, 2014
• Effective date (End): December 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Mariele Mucio Pedroso
• Grantee: Milena Alves
• Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, is recognized as a serious public health problem in Brazil and worldwide. The availability of drugs for the disease is very limited and therefore it is estimated that only 1% of infected individuals receiving some type of treatment. Many natural and synthetic products are evaluated for trypanocidal activity in the treatment of this disease, as is the case of compounds derived from gallic acid , dodecyl gallate and catechin gallate epigalocatequinaque . The antioxidant, antiviral and antitumor activity of these compounds as well as their use depends on the knowledge and understanding of their physicochemical properties. In this context, this project aims to develop an electroanalytical methodology to quantify the compounds dodecyl gallate and epigallocatechin gallate in solution which is an essential factor for its potential clinical use. These data will contribute to the studies of encapsulation and evaluation of controlled release rate of these promising drugs against Chagas disease (FAPESP 2013/05448-0). (AU)