| Grant number: | 13/20904-1 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | December 01, 2013 |
| Effective date (End): | May 31, 2014 |
| Field of knowledge: | Health Sciences - Pharmacy |
| Principal researcher: | Joilson de Oliveira Martins |
| Grantee: | Isis Fieri |
| Home Institution: | Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 10/02272-0 - Effect of insulin on lung inflammation in animal with sepsis, innate immunit,activation of insulin gene (BGK) and insulin receptors (IR)-A and IR-B, AP.JP |
Abstract Vitamin D is a steroid hormone synthesized in the skin, which is involved in many physiological processes (homeostasis of phosphorus and calcium, modulation of the immune system) and pathological (autoimmune diseases such as type 1 diabetes mellitus). This disease is characterized by destruction of beta cells through the action of pancreatic B lymphocytes, macrophages, T cells, CD4 + and CD8 + T cells that culminates in slow, progressive loss of insulin secretion. Studies have been demonstrated that vitamin D stimulates phagocytosis of the bacteria by macrophages as well as production of interleukin (IL)-1 and prostaglandin (PG)-E2. The aim of this work is to study the relationship between vitamin D supplementation, the expression of the vitamin D receptor (VDR - Western blotting) of peritoneal lavage macrophages (LP) and bronchoalveolar lavage (BAL) and the immune response in diabetic mice (alloxan 60 mg / kg, iv) and healthy. Thus, this project aims to expand the knowledge of the action of vitamin D in immunity, thereby improving the quality of life of diabetic patients, allowing better control of the disease, since this hormone replacement therapy is easy to perform and inexpensive. (AU) | |