Effect of insulin on lung inflammation in animal with sepsis, innate immunit,activation of insulin gene (BGK) and insulin receptors (IR)-A and IR-B

• Grant number: 10/02272-0
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: March 01, 2011
• End date: February 28, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Joilson de Oliveira Martins
• Grantee: Joilson de Oliveira Martins
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 13/20904-1 - Study of the expression of Vitamin D receptor in peritoneal and alveolar macrophages in healthy and diabetic mice, BP.IC; 12/23998-4 - Influence of vitamin D receptor expression (VDR and TLR) in macrophages in the model of experimental diabetes mellitus, BP.MS; 13/10307-6 - Study of cytokine secretion in a model of carrageenan-induced peritonitis in healthy and diabetic mice, BP.IC; + associated scholarships 12/06617-7 - Role of insulin in the effectiveness of allergic pulmonary inflammation in healthy or diabetic mice, BP.MS; 12/06652-7 - CELLULAR AND MOLECULAR ASPECTS INVOLVED IN THE INFLAMMATORY RESPONSE INDUCED BY CARRAGEENAN IN HEALTHY OR DIABETIC MICE, BP.PD; 11/12298-9 - The insulin intervention in the expression of adhesion molecules in an experimental model of sepsis, BP.IC; 10/20501-6 - Effect of insulin on lung inflammation in animal with sepsis, innate immunity,activation of insulin gene (bgk) and insulin receptors (ir)-a and ir-b, BP.JP - associated scholarships

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASAGRANDE, FELIPE BECCARIA; FERREIRA, SABRINA DE SOUZA; BARBOSA NUNES, FERNANDA PEIXOTO; DAL'MAS ROMERA, LAVINIA MARIA; DOS SANTOS, SUELEN SILVANA; GALVAO TESSARO, FERNANDO HENRIQUE; KNOX DE SOUZA, PAULA REGINA; ALMEIDA, SANDRO ROGERIO; MARTINS, JOILSON OLIVEIRA. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. JOURNAL OF DIABETES RESEARCH, 2018. (17/11540-7, 12/06652-7, 14/05214-1, 12/06617-7, 10/02272-0)

SUNAHARA, KAREN K. S.; NUNES, FERNANDA P. B.; BAPTISTA, MARISA A. P.; STRELL, CARINA; SANNOMIYA, PAULINA; WESTERBERG, LISA S.; MARTINS, JOILSON O.. Insulin Influences Autophagy Response Distinctively in Macrophages of Different Compartments. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 34, n. 6, p. 2017-2026, 2014. (10/02272-0)

KNOX DE SOUZA, PAULA R.; FERREIRA, SABRINA S.; NUNES, FERNANDA P. B.; CASAGRANDE, FELIPE B.; TESSARO, FERNANDO H. G.; SILVA, MARIANA C. F.; MIRANDA COSTA CRUZ, JOSE WALBER; MAMIZUKA, ELSA M.; MARTINS, JOILSON O.. Cytokine and Adhesion Molecule Expression Induced by Different Strains of Staphylococcus aureus in Type 1 Diabetic Rats: Role of Insulin. FRONTIERS IN IMMUNOLOGY, v. 9, JAN 17 2019. (17/11540-7, 12/06652-7, 14/05214-1, 10/02272-0)

NOLASCO, EDUARDO L.; ZANONI, FERNANDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; FREITAS, LUIZA A.; SILVA, MARIANA C. F.; MARTINS, JOILSON O.. Insulin Modulates Liver Function in a Type I Diabetes Rat Model. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 36, n. 4, p. 1467-1479, 2015. (14/05214-1, 10/02272-0)

RAJASEKARAN, SUBU SURENDRAN; ILLIES, CHRISTOPHER; SHEARS, STEPHEN B.; WANG, HUANCHEN; AYALA, THAIS S.; MARTINS, JOILSON O.; DARE, ELISABETTA; BERGGREN, PER-OLOF; BARKER, CHRISTOPHER J.. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic beta-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. CELLULAR SIGNALLING, v. 42, p. 127-133, JAN 2018. (14/05214-1, 10/02272-0)

GALVAO TESSARO, FERNANDO HENRIQUE; AYALA, THAIS SOPRANI; BELLA, LEONARDO MENDES; MARTINS, JOILSON OLIVEIRA. Macrophages from a type 1 diabetes mouse model present dysregulated P13K/AKT, ERK 1/2 and SAPK/JNK levels. Immunobiology, v. 225, n. 2, MAR 2020. (14/05214-1, 17/11540-7, 10/02272-0)

TESSARO, FERNANDO H. G.; AYALA, THAIS S.; MARTINS, JOILSON O.. Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus. BIOMED RESEARCH INTERNATIONAL, 2015. (10/02272-0)

BELLA, LEONARDO M.; FIERI, ISIS; TESSARO, FERNANDO H. G.; NOLASCO, EDUARDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; AZEVEDO, CAROLINA B.; MARTINS, JOILSON O.. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BIOMED RESEARCH INTERNATIONAL, 2017. (13/20904-1, 12/23998-4, 14/05214-1, 10/02272-0)

RAJASEKARAN, SUBU SURENDRAN; KIM, JAEYOON; GABOARDI, GIAN-CARLO; GROMADA, JESPER; SHEARS, STEPHEN B.; DOS SANTOS, KAREN TIAGO; NOLASCO, EDUARDO LIMA; FERREIRA, SABRINA DE SOUZA; ILLIES, CHRISTOPHER; KOHLER, MARTIN; et al. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells. CELLULAR SIGNALLING, v. 46, p. 120-128, JUN 2018. (14/05214-1, 10/02272-0, 17/11540-7)

FERREIRA, SABRINA S.; NUNES, FERNANDA P. B.; CASAGRANDE, FELIPE B.; MARTINS, JOILSON O.. Insulin Modulates Cytokine Release, Collagen and Mucus Secretion in Lung Remodeling of Allergic Diabetic Mice. FRONTIERS IN IMMUNOLOGY, v. 8, JUN 9 2017. (14/05214-1, 12/06617-7, 10/02272-0)

TESSARO, FERNANDO H. G.; AYALA, THAIS S.; NOLASCO, EDUARDO L.; BELLA, LEONARDO M.; MARTINS, JOILSON O.. Insulin Influences LPS-Induced TNF-alpha and IL-6 Release Through Distinct Pathways in Mouse Macrophages from Different Compartments. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 42, n. 5, p. 2093-2104, 2017. (14/05214-1, 17/15625-7, 12/23998-4, 10/02272-0)

BELLA, LEONARDO M.; FIERI, ISIS; TESSARO, FERNANDO H. G.; NOLASCO, EDUARDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; AZEVEDO, CAROLINA B.; MARTINS, JOILSON O.. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BIOMED RESEARCH INTERNATIONAL, v. 2017, p. 10-pg., 2017-01-01. (13/20904-1, 12/23998-4, 10/02272-0, 14/05214-1)

CASAGRANDE, FELIPE BECCARIA; FERREIRA, SABRINA DE SOUZA; BARBOSA NUNES, FERNANDA PEIXOTO; DAL'MAS ROMERA, LAVINIA MARIA; DOS SANTOS, SUELEN SILVANA; GALVAO TESSARO, FERNANDO HENRIQUE; KNOX DE SOUZA, PAULA REGINA; ALMEIDA, SANDRO ROGERIO; MARTINS, JOILSON OLIVEIRA. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. JOURNAL OF DIABETES RESEARCH, v. 2018, p. 11-pg., 2018-01-01. (10/02272-0, 12/06617-7, 17/11540-7, 12/06652-7, 14/05214-1)

TESSARO, FERNANDO H. G.; AYALA, THAIS S.; MARTINS, JOILSON O.. Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus. BIOMED RESEARCH INTERNATIONAL, v. 2015, p. 8-pg., 2015-01-01. (10/02272-0)

BARKER, CHRISTOPHER J.; TESSARO, FERNANDO HENRIQUE GALVAO; FERREIRA, SABRINA DE SOUZA; SIMAS, RAFAEL; AYALA, THAIS S.; KOHLER, MARTIN; RAJASEKARAN, SUBU SURENDRAN; MARTINS, JOILSON O.; DARE, ELISABETTA; BERGGREN, PER-OLOF. XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush. Diabetes, v. 70, n. 1, p. 111-118, JAN 2021. (14/05214-1, 10/02272-0, 17/11540-7)