The matrix of decellularized organs potentially maintains the three-dimensional architecture and biochemical composition, as well as the original tissue microvasculature. These properties make the lung decellularized very promising for generating bioartificial lung function, since it provides better rebuild the microenvironment in vivo. The existing scientific evidence supporting the idea that the physical microenvironment contributes significantly to the modulation of the differentiation of mesenchymal stem cells, embryonic and bone marrow derived. However, no data are available to date, showing the fate of induced pluripotent stem cells could be specifically affected by physical stimuli. The mechanical behavior of resistance and compliance of decellularized lungs in the process of repopulation with stem cells is still unknown. Therefore, this study aims to investigate in an experimental animal model, the behavior of the mechanical properties of decellularized lungs of rats by different decellularization techniques and during the process of stem cell repopulation. The mechanical parameters will be collected through the occlusion method at the end of inspiration. For the realization of this project is a partnership between the Experimental Laboratory of Mechanics Cardiorespiratory Program Graduate Masters and PhD in Rehabilitation Sciences UNINOVE of the study group of Biophysics and Bioengineering Laboratory, Barcelona University - Spain under the responsibility of Prof. Daniel Navajas and Prof. Ramon Farre.
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