Canine brucellosis: evaluation of genetic diversity and development of new tools for molecular typing for Brucella canis

• Grant number: 14/00889-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2014
• Effective date (End): August 31, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Jane Megid
• Grantee: Acácia Ferreira Vicente
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 14/21544-1 - Molecular characterization of Brucella canis strains circulating in Brazil, BE.EP.DR

Abstract

Brucellosis is a zoonosis which has a great impact on the public health and economic worldwide. Canine brucelose, often diagnosed in Brazil, has its importance in the public health given the relation animal/human. From the economic point of view causes losses in kennels due to reproductive losses and difficulty or impossibility of therapeutic. Genotyping of pathogens is essential for monitoring transmission chains, which is required for local and global disease surveillance. This project id intended to evaluate the genetic diversity of B. canis population in the São Paulo state comparing with European and Asian strains by MLVA-16; analyze in silico of genes supposed involved in drug resistance, virulence determinants and mobile genetic elements, and develop of a new epidemiological tool through sequencing complete genome of these strains. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VICENTE, ACACIA FERREIRA; GIRAULT, GUILLAUME; CORDE, YANNICK; MIONI, MATEUS SOUZA RIBEIRO; KEID, LARA BORGES; JAY, MARYNE; MEGID, JANE; MICK, VIRGINIE. New insights into phylogeography of worldwide Brucella canis isolates by comparative genomics-based approaches: focus on Brazil. BMC Genomics, v. 19, AUG 28 2018. (14/00889-0)

GIRAULT, GUILLAUME; VICENTE, ACACIA FERREIRA; CORDE, YANNICK; RIBEIRO MIONI, MATEUS SOUZA; KEID, LARA BORGES; JAY, MARYNE; MEGID, JANE; MICK, VIRGINIE. Genome Sequences of Five Brucella canis Strains Isolated from Different Countries throughout the World. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 7, n. 14, OCT 2018. (14/00889-0)