Evaluation of infant exposure to psychoactive substances during lactation by toxicological analysis in breast milk

• Grant number: 14/04107-7
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): July 01, 2014
• Effective date (End): April 30, 2016
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal Investigator: Mauricio Yonamine
• Grantee: Gabriela de Oliveira Silveira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Maternal breastfeeding is related with nutritional, immunological, affective, economic, and social benefits. Most licit and illicit substances consumed by the nursing mother might be excreted in breast milk, which may cause potential harmful effects to the breastfed infant at short and long terms. Although the knowledge about the psychoactive substances during lactation is increasing, there is still few information on the levels in which these substances are excreted by breast milk and many questions about the possible effects of these substances in the infant during the nursing period still remain. Breast milk is an unconventional matrix that can be used to assess infant exposure to drugs, and its main advantage is its easy and non-invasive collection. However, the extraction of substances from breast milk is an analytical challenge because of its high protein and fat content and changing composition during the postpartum period. In this study, analytical methods will be carried to determine psychoactive substances (such as cocaine, cocaethylene, norcocaine, tetraidrocanabinol, canabinol, canabidiol and nicotine) in milk samples by using chromatographic techniques. After the development and validation of the method, it will be applied in milk samples from municipal public hospitals members of the "Rede de Proteção à Mãe Paulistana". This project can generate data to provide an overview of this phenomenon in São Paulo city with the aim to evaluate the risk for children due to the presence of these substances in breast milk.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVEIRA, GABRIELA DE OLIVEIRA; LODDI, SILVANA; RODRIGUES DE OLIVEIRA, CAROLINA DIZIOLI; ZUCOLOTO, ALEXANDRE DIAS; GIMENEZ FRUCHTENGARTEN, LIGIA VERAS; YONAMINE, MAURICIO. Headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of cannabinoids in human breast milk. Forensic Toxicology, v. 35, n. 1, p. 125-132, JAN 2017. (15/15700-3, 14/04107-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVEIRA, Gabriela de Oliveira. Evaluation of infant exposure to psychoactive substances during lactation by toxicological analysis in breast milk.. 2016. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.