Metabolomics profile of patients with type 2 diabetes and obesity after Roux en Y gastric bypass

• Grant number: 13/23355-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2014
• Effective date (End): August 31, 2018
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Dan Linetzky Waitzberg
• Grantee: Natasha Mendonça Machado
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass, AP.TEM
• Associated scholarship(s): 16/01259-6 - Metabolomic profile of patients with type 2 diabetes and obesity after Roux en Y gastric bypass, BE.EP.DR

Abstract

Type 2 Diabetes Mellitus (T2DM) became a worldwide epidemic with growing proportions, and obesity is an important characteristic of its development. In the therapeutic context, the Roux en Y gastric Bypass (RYGB) has been considered an effective method, capable not only of promoting weight loss, but also supporting T2DM complete resolution. Despite these clinical findings, the glycemic control and metabolic changes phenomena are still being largely discussed even as to the conceptual definition of T2DM. In this sense, the use of literature-established methods to perform a detailed metabolomic investigation is relevant so as to identify metabolites from carbohydrate metabolic pathways. Therefore, the analysis of biological fluids associated with biopsies sections of gastrointestinal tract represents an elementary aspect for identification and understanding of metabolic alterations. Furthermore, this approach has an unprecedented nature and aims to expand the comprehension of all the perspectives involved in T2DM clinical manifestations, an issue of public health interest.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALA, PRISCILA; BELARMINO, GILIANE; MACHADO, NATASHA MENDONCA; CARDINELLI, CAMILA SIQUEIRA; AL ASSAL, KARINA; SILVA, MARIANE MARQUES; FONSECA, DANIELLE CRISTINA; ISHIDA, ROBSON KIYOSHI; SANTO, MARCO AURELIO; HOURNEAUX DE MOURA, EDUARDO GUIMARAES; et al. The SURMetaGIT study: Design and rationale for a prospective pan-omics examination of the gastrointestinal response to Roux-en-Y gastric bypass surgery. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v. 44, n. 6, p. 1359-1375, DEC 2016. (15/22820-5, 11/09612-3, 14/05220-1, 13/03246-0, 14/07742-5, 12/23762-0, 16/01259-6, 13/23355-9)

MACHADO, NATASHA MENDONCA; CARDINELLI, CAMILA DE SIQUEIRA; SHEN, TONG; SANTO, MARCO AURELIO; TORRINHAS, RAQUEL SUSANA; WAITZBERG, DAN LINETZKY. Cholecystectomy - a potential selection bias in studies assessing the metabolic effects of bariatric surgeries. SCIENTIFIC REPORTS, v. 10, n. 1, JUN 30 2020. (16/01259-6, 13/23355-9, 11/09612-3, 14/05220-1)

MACHADO, NATASHA MENDONCA; TORRINHAS, RAQUEL SUSANA; SALA, PRISCILA; ISHIDA, ROBSON KIYOSHI; MOTA SIQUEIRA GUARDA, ISMAEL FRANCISCO; HOURNEAUX DE MOURA, EDUARDO GUIMARAES; SAKAI, PAULO; SANTO, MARCO AURELIO; WAITZBERG, DAN LINETZKY. Type 2 Diabetes Metabolic Improvement After Roux-en-Y Gastric Bypass May Include a Compensatory Mechanism That Balances Fatty Acid beta and omega Oxidation. Journal of Parenteral and Enteral Nutrition, v. 44, n. 8, JUL 2020. (13/23355-9, 16/01259-6, 11/09612-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MACHADO, Natasha Mendonça. Impact of Roux-em-Y gastric bypass on metabolomic profile of obese women with type 2 diabetes. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.