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Metabolomics profile of patients with type 2 diabetes and obesity after Roux en Y gastric bypass

Grant number: 13/23355-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): August 31, 2018
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Dan Linetzky Waitzberg
Grantee:Natasha Mendonça Machado
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass, AP.TEM
Associated scholarship(s):16/01259-6 - Metabolomic profile of patients with type 2 diabetes and obesity after Roux en Y gastric bypass, BE.EP.DR

Abstract

Type 2 Diabetes Mellitus (T2DM) became a worldwide epidemic with growing proportions, and obesity is an important characteristic of its development. In the therapeutic context, the Roux en Y gastric Bypass (RYGB) has been considered an effective method, capable not only of promoting weight loss, but also supporting T2DM complete resolution. Despite these clinical findings, the glycemic control and metabolic changes phenomena are still being largely discussed even as to the conceptual definition of T2DM. In this sense, the use of literature-established methods to perform a detailed metabolomic investigation is relevant so as to identify metabolites from carbohydrate metabolic pathways. Therefore, the analysis of biological fluids associated with biopsies sections of gastrointestinal tract represents an elementary aspect for identification and understanding of metabolic alterations. Furthermore, this approach has an unprecedented nature and aims to expand the comprehension of all the perspectives involved in T2DM clinical manifestations, an issue of public health interest.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALA, PRISCILA; BELARMINO, GILIANE; MACHADO, NATASHA MENDONCA; CARDINELLI, CAMILA SIQUEIRA; AL ASSAL, KARINA; SILVA, MARIANE MARQUES; FONSECA, DANIELLE CRISTINA; ISHIDA, ROBSON KIYOSHI; SANTO, MARCO AURELIO; HOURNEAUX DE MOURA, EDUARDO GUIMARAES; SAKAI, PAULO; MOTA SIQUEIRA GUARDA, ISMAEL FRANCISCO; COTRIM GUERREIRO DA SILVA, ISMAEL DALE; RODRIGUES, AGATHA SACRAMENTO; DE BRAGANCA PEREIRA, CARLOS ALBERTO; HEYMSFIELD, STEVEN; DORE, JOEL; MATOS DE MIRANDA TORRINHAS, RAQUEL SUSANA; GIANNELLA-NETO, DANIEL; WAITZBERG, DAN LINETZKY. The SURMetaGIT study: Design and rationale for a prospective pan-omics examination of the gastrointestinal response to Roux-en-Y gastric bypass surgery. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v. 44, n. 6, p. 1359-1375, DEC 2016. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MACHADO, Natasha Mendonça. Impact of Roux-em-Y gastric bypass on metabolomic profile of obese women with type 2 diabetes. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.