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Kiss1 neurons activation by pheromonal stimulus

Grant number: 14/08755-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Renata Frazão
Grantee:Fernanda Tais Haubenthal
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which play an essential role in the neuroendocrine regulation of GnRH secretion. Kiss1 expressing neurons has been described in the anteroventral periventricular, anterior periventricular nucleus (AVPV/PeN), arcuate nucleus (Arc) and other areas as the medial nucleus of amygdala (MeA). Kiss1 gene has variable expression on the MeA depending on the sex hormones levels, both in males and females rodents. In rodents pheromones and others olfactory substances regulate reproduction functions, the MeA is considered the primary station that transmits the essential information regarding reproduction to GnRH and the AVPV nuclei. The MeA is also implicated in social and emotional behaviors. However, the importance of Kiss1 gene in this nucleus is not known. The present study will evaluate whether pheromonal stimulation activate neurons that express Kiss1 gene on MeA as well in the AVPV/PeN and Arc nuclei. The results will allow us to assess whether the Kiss1 expressing neurons, specially on MeA, are part of the olfactory-hypothalamic circuit which regulate reproduction.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, LEANDRO BUENO; HAUBENTHAL, FERNANDA TAIS; SILVEIRA, MARINA AUGUSTO; BOHLEN, TABATA MARIZ; METZGER, MARTIN; DONATO JR, JOSE; FRAZAO, RENATO. Conspecific odor exposure predominantly activates non-kisspeptin cells in the medial nucleus of the amygdala. Neuroscience Letters, v. 681, p. 12-16, AUG 10 2018. Web of Science Citations: 3.

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