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Identification of eQTLs associated with the deposition and composition of intramuscular fat in Nellore breed

Grant number: 14/11871-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2014
Effective date (End): July 31, 2018
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Luiz Lehmann Coutinho
Grantee:Aline Silva Mello Cesar
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:12/23638-8 - Molecular basis of meat quality in Nelore beef cattle, AP.TEM
Associated scholarship(s):14/22884-0 - Identification of eQTLs associated with the deposition and composition of intramuscular fat in Nellore breed, BE.EP.PD


The quantity and composition of intramuscular fat (IMF) influence the sensory characteristics, nutritional value of beef and human health, since the profile of its fatty acids may present in diverse way as genetics, management and nutrition of animal origin. The deposition and fat composition are determined by many genes that participate directly or indirectly in adipogenesis and lipid metabolism. In the last decade, we have witnessed a major breakthrough in the area of the bovine genome that resulted in the complete sequencing of the genome, the development of strategies for sequencing RNA to study gene expression chips and high-density SNP genotyping. The aim of this study is to map regions of eQTLs across the bovine genome to characterize the genetic architecture involved in gene expression associated with the deposition and composition of intramuscular fat. Samples of Longissimus dorsi muscle from Nellore steers will be used for the total mRNA sequencing and to obtaining the transcriptome. The eQTL regions identified in this project may contribute to the knowledgement of the biological mechanisms involved in the biosynthesis of fatty acids in cattle. These results will form the basis of data from the Thematic Project " Molecular basis of meat quality in Nelore cattle " (Process 2012/23638-8), contributing to an understanding of the regulation of biological process involved with various phenotypes of economic interest.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAPPELER, BERNA I. G.; REGITANO, LUCIANA C. A.; POLETI, MIRELE D.; CESAR, ALINE S. M.; MOREIRA, GABRIEL C. M.; GASPARIN, GUSTAVO; COUTINHO, LUIZ L. MiRNAs differentially expressed in skeletal muscle of animals with divergent estimated breeding values for beef tenderness. BMC MOLECULAR BIOLOGY, v. 20, JAN 3 2019. Web of Science Citations: 2.
CESAR, ALINE S. M.; REGITANO, LUCIANA C. A.; REECY, JAMES M.; POLETI, MIRELE D.; OLIVEIRA, PRISCILA S. N.; DE OLIVEIRA, GABRIELLA B.; MOREIRA, GABRIEL C. M.; MUDADU, MAURICIO A.; TIZIOTO, POLYANA C.; KOLTES, JAMES E.; FRITZ-WATERS, ELYN; KRAMER, LUKE; GARRICK, DORIAN; BEIKI, HAMID; GEISTLINGER, LUDWIG; MOURAO, GERSON B.; ZERLOTINI, ADHEMAR; COUTINHO, LUIZ L. Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits. BMC Genomics, v. 19, JUN 27 2018. Web of Science Citations: 3.
CESAR, ALINE S. M.; REGITANO, LUCIANA C. A.; POLETI, MIRELE D.; ANDRADE, SONIA C. S.; TIZIOTO, POLYANA C.; OLIVEIRA, PRISCILA S. N.; FELICIO, ANDREZZA M.; DO NASCIMENTO, MICHELE L.; CHAVES, AMALIA S.; LANNA, DANTE P. D.; TULLIO, RYMER R.; NASSU, RENATA T.; KOLTES, JAMES E.; FRITZ-WATERS, ERIC; MOURAO, GERSON B.; ZERLOTINI-NETO, ADHEMAR; REECY, JAMES M.; COUTINHO, LUIZ L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, v. 17, NOV 22 2016. Web of Science Citations: 8.

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