Obtaining ferromagnetic nanoparticles through hydrothermal systhesis assisted by microwave irradiation to aplicattion in magnetohyperthermia

• Grant number: 14/16993-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2014
• End date: September 30, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Alexandre Zirpoli Simões
• Grantee: Breno Gonçalves Galvão Freire
• Host Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil
• Associated research grant: 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID

Abstract

A variety of clinical procedures has been developed for cancer therapy over the last century. Cancer is characterized by out of control cell growth. A tumor is an abnormal lump or collection of these cells. Tumors can be benign or malignant. In both cases, cells multiply in a disorderly manner. Benign tumors tend to grow slowly and do not spread. Malignant tumors can grow rapidly, invade and destroy nearby normal tissues, and spread throughout the body, phenomenon known as metastasis. Surgery, chemotherapy, and radiation are the most common types of cancer treatment. The development of hyperthermia improved cancer therapy and, in liver cancer, radiotherapy and surgery are limited. Hyperthermia can also enhance the effects of chemotherapy or radiotherapy. This treatment is based on the use of ferromagnetic nanoparticles made of Yƒ3Fe5-xAlxO12 (x entre 1,6 e 1,7) to remotely induce local heat when a radiofrequency magnetic field is applied, provoking a temperature increase (41-43 °C) in those tissues and organs where the tumoral cells are present. These nanoparticles have interesting physical properties, such as high saturation magnetization and controllable Curie temperature, characteristics that are particularly interesting for hyperthermia. This project aims to synthesize and characterize ferromagnetic nanoparticles Yƒ3Fe5-xAlxO12 (x entre 1,6 e 1,7) using hydrothermal technique assisted by microwave. This technique is less expensive and more efficient than conventional autoclave methods, generating nanoparticles more homogeneous and crystalline in lower temperatures during the synthesis. The objective of this project is study the necessary conditions to utilize these nanoparticles in liver cancer treatment by hyperthermia.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BORSARI, E.; FREIRE, B. G. G.; GARCIA, F. G.; SILVA, M. S.; SILVA, C. C.; SIMOES, A. Z.. Microwave-hydrothermal synthesis of Y3Fe3.35Al1.65O12 nanoparticles for magneto-hyperthermia application. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, v. 29, n. 21, p. 18020-18029, NOV 2018. (14/16993-1, 13/07296-2)