Preparation of CoreShell structured PLA-Gelatin-TiO2 tri-component nanofibers by coaxial electrospinning

• Grant number: 14/16966-4
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: November 29, 2014
• End date: February 27, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Anderson de Oliveira Lobo
• Grantee: Tatiane Venturott Toniato
• Supervisor: Thomas Jay Webster
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• Institution abroad: Northeastern University, United States
• Associated to the scholarship: 13/08341-1 - Electrospinning of polymeric nanofibers of poly-acid lactic with incorporated titanium dioxide nanoparticles, BP.IC

Abstract

There is a significant need for materials that both prevent bacteria adhesion and rapidly form a strong bone-to-implant interface to achieve biomaterial stability. In this way, this project presents the novel poly(lactic acid), gelatin and TiO2 hybrid nanofibres that will be produced via coaxial electrospinning technique. Scanning electron microscopy, transmission electron microscopy, X-ray difractometry, X-ray dispersive spectroscopy and optical spectroscopy will be used to morphological and structural characterization. Bioassays with the nanofibers produced will also be performed. They will succeed in partnership with the Laboratory of Nanomedicine at Northeastern University in Boston, USA. It is expected to obtain PLA/Gelatin/TiO2 hybrid nanofibers in order to obtain bone tissue regeneration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TONIATTO, T. V.; RODRIGUES, B. V. M.; MARSI, T. C. O.; RICCI, R.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Nanostructured poly (lactic acid) electrospun fiber with high loadings of TiO2 nanoparticles: Insights into bactericidal activity and cell viability. Materials Science & Engineering C-Materials for Biological Applications, v. 71, p. 381-385, FEB 1 2017. (11/17877-7, 15/08523-8, 13/08341-1, 11/20345-7, 14/16966-4)