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Mitochondria as a key element on stress response in plants

Grant number: 14/17634-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2014
Effective date (End): October 31, 2019
Field of knowledge:Biological Sciences - Genetics - Plant Genetics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Paulo Arruda
Grantee:Pedro Paulo Augusto Fabiano Arantes Pereira Barreto
Home Institution: Centro de Biologia Molecular e Engenharia Genética (CBMEG). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/23218-0 - The Genomics for Climate Change Research Center, AP.PCPE
Associated scholarship(s):17/22745-9 - Unravelling the impact of UCP1 overexpression in barley and upon stability of Group VII ethylene response factor transcription factors in Arabidopsis, BE.EP.PD   15/24881-1 - Unraveling the effects of UCP1 overexpression during reproduction and upon stability of Group VII ethylene response factor transcription factors, BE.EP.PD


The mitochondria plays a central role in aerobic respiration and energy metabolism in complex organisms. The mitochondrial energy metabolism in turn is the main source of reactive oxygen species (ROS). To cope with the significant generation of ROS and its damaging consequences for cellular metabolism, the mitochondria holds a potent antioxidant apparatus with reflections in mitochondria, cytoplasm and other cell organelles. Although during the evolutionary process mitochondria have maintained its own genome, the majority of mitochondrial proteins are encoded by the nuclear genome, while the mitochondrial genome encodes a small number of proteins, including those involved in the complexes of the electron transport chain (ETC). Thus, changes in mitochondrial metabolism dictated by the processes of differentiation and development or adaptation to adverse environmental conditions require close communication between the mitochondria, the nucleus and other cellular compartments. In plants, the regulatory elements involved in this process are still poorly understood. Recently we demonstrated that overexpression of mitochondrial uncoupling protein 1 (UCP1) in tobacco plants (Nicotiana tabacum) induces mitochondrial biogenesis, alters mitochondrial morphology and amplifies an extensive anti-stress response. These plants overexpressing UCP1 exhibit significant improvement in biological performance under various abiotic stress conditions. In this project we propose to identify candidate genes that interfere with communication between the mitochondria and other cellular compartments aimed at producing maize plants (Zea mays) more resistant to abiotic stresses. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARRUDA, PAULO; BARRETO, PEDRO. Lysine Catabolism Through the Saccharopine Pathway: Enzymes and Intermediates Involved in Plant Responses to Abiotic and Biotic Stress. FRONTIERS IN PLANT SCIENCE, v. 11, MAY 21 2020. Web of Science Citations: 1.
BARRETO, PEDRO; YASSITEPE, JULIANA E. C. T.; WILSON, ZOE A.; ARRUDA, PAULO. Mitochondrial Uncoupling Protein 1 Overexpression Increases Yield in Nicotiana tabacum under Drought Stress by Improving Source and Sink Metabolism. FRONTIERS IN PLANT SCIENCE, v. 8, NOV 1 2017. Web of Science Citations: 4.
BARRETO, PEDRO; OKURA, VAGNER; PENA, IZABELLA A.; MAIA, RENATO; MAIA, IVAN G.; ARRUDA, PAULO. Overexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response in Nicotiana tabacum leaves. Journal of Experimental Botany, v. 67, n. 1, p. 301-313, JAN 2016. Web of Science Citations: 4.

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