The Genomics for Climate Change Research Center

• Grant number: 16/23218-0
• Support Opportunities: Research Grants - Research Centers in Engineering Program
• Start date: August 01, 2018
• End date: July 31, 2028
• Field of knowledge: Biological Sciences - Genetics - Plant Genetics
• Principal Investigator: Edi Lúcia Sartorato
• Grantee: Edi Lúcia Sartorato
• Host Institution: Centro de Biologia Molecular e Engenharia Genética (CBMEG). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City: BrasíliaCampinas
• Partner institutions: Ministério da Agricultura, Pecuária e Abastecimento (Brasil). Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Embrapa Sede
• Pesquisadores principais:( Atuais ): Isabel Rodrigues Gerhardt ; Juliana Erika de Carvalho Teixeira Yassitepe ; Márcio José da Silva ; Ricardo Augusto Dante ; Sylvia Morais de Sousa Tinoco
• Pesquisadores principais:( Anteriores ): Geraldo Magela de Almeida Cançado
• Associated researchers: Benilton de Sá Carvalho ; Gonçalo Amarante Guimarães Pereira ; Joice Machado Bariani ; Luiz Antonio Falaguasta Barbosa ; Marcelo Falsarella Carazzolle ; Marcelo Menossi Teixeira ; Maria Ester Soares Dal Poz ; Marília Gaspar Maïs ; Michel Georges Albert Vincentz ; Paula Malloy Mota Diniz ; Paulo Sergio de Paula Herrmann Junior ; Rafael Silva Oliveira ; Rafael Vasconcelos Ribeiro ; Renato Vicentini dos Santos ; Sylvia Morais de Sousa Tinoco
• Associated research grant(s): 22/10163-3 - 7th International Plant Phenotyping Symposium (IPPS 2022), AR.EXT; 22/09418-7 - Developing a platform for fast and efficient evaluation of CRISPR/Cas-based genome editing tools in plant cells, AV.EXT; 21/13196-7 - Multi-User equipment approved in grant 2016/23218-0 - Illumina NextSeq 2000, AP.EMU; 19/05676-9 - Project for implementation of multiuser equipment granted in aid ref .: process: 2016 / 23218-0 - modality - 3 1 automatic photosynthesis analyzer, AP.EMU
• Associated scholarship(s): 25/06130-0 - Digital phenotyping to evaluate the response of maize seedlings to water stress., BP.TT; 25/09608-9 - Analysis of plant growth-promoting bacteria of Vellozia spp., BP.TT; 24/23222-3 - Assembly and comparative analysis of genomes of two maize landraces., BP.TT; + associated scholarships 24/23536-8 - Genotyping of genetically modified corn events GCCRC "pipeline", BP.TT; 24/23649-7 - Maize cultivation and phenotyping in a greenhouse, BP.TT; 24/23440-0 - Use of microbial diversity to improve the performance of growth-promoting strains: exploring the microbiome of Velloziaceae species from the rupestrian fields, BP.TT; 24/23625-0 - Stress response strategies through lysine catabolism, BP.TT; 24/17446-6 - Development of a digital phenotyping platform for evaluation of maize genotypes, BP.PD; 24/15620-9 - Regulation of the stress response mediated by lysine catabolism, BP.DR; 24/12651-0 - Exploring Plant-Microorganism Interactions in Velloziaceae from the campos rupestres via Metagenomics and Metatranscriptomics, BP.PD; 24/11068-0 - Assembly and comparative analysis of Vellozia species: a study to understand adaptation in response to drought, BP.TT; 24/12315-0 - Strategy of vector construction for modifying candidate genes from the GCCRC pipeline, BP.TT; 24/08554-0 - Use of morphogenetic genes to increase transformation efficiency in maize., BP.TT; 24/09906-7 - Genotyping of transgenic and edited maize events generated in the transformation pipeline of GCCRC, BP.TT; 24/08517-7 - Characterization of genes with unknown function that are involved in the response to drought stress in Arabidopsis thaliana: potential targets for the development of biotechnological assets applicable to maize crops, BP.TT; 24/08748-9 - Molecular characterization of transgenic and edited events produced by the GCCRC corn transformation pipeline., BP.TT; 24/00674-6 - Science Communication on Technological Solutions for Sustainable Agriculture and Climate Change, BP.JC; 23/11640-2 - Meta-GWAS aiming to identify natural genetic variation for water stress tolerance, BP.TT; 22/16731-3 - The Genomics for Climate Change Research Center, BP.TT; 23/02553-9 - Genetic transformation of maize via Agrobacterium tumefaciens, BP.TT; 22/15173-7 - Characterization of genes of unknown function involved in drought response in Arabidopsis thaliana: potential targets for the development of biotechnological assets, BP.PD; 22/10261-5 - The Genomics for Climate Change Research Center, BP.TT; 22/09879-4 - Identifying tropical maize genetic variability for adaptation to drought stress, BE.PQ; 22/08797-4 - Characterization of the phylogenetic and functional diversity of soils and Velloziaceae species associated microorganisms from rupestrian grasslands, BP.TT; 22/04930-1 - Maize cultivation, Introgression of genes of interest and Phenotyping in a greenhouse, BP.TT; 22/04441-0 - The Genomics for Climate Change Research Center, BP.TT; 22/04929-3 - Improvements of corn genetic transformation protocol at GCCRC, BP.TT; 21/08486-6 - Genetic transformation of maize and Arabidopsis thaliana for functional evaluation of genes aiming at tolerance to abiotic stresses, BP.PD; 21/04953-9 - Isolation and characterization of microorganisms associated with plants adapted to limiting nutritional conditions, BP.PD; 21/00962-3 - The Genomics for Climate Change Research Center, BP.TT; 21/01003-0 - The Genomics for Climate Change Research Center, BP.TT; 20/16717-5 - The Genomics for Climate Change Research Center, BP.TT; 20/10397-9 - Genetic transformation of maize and Arabidopsis thaliana for functional evaluation of genes for tolerance to abiotic stresses, BP.PD; 20/10677-1 - Genetic transformation of maize mediated by Agrobacterium tumefaciens to obtaining resistance to abiotic stresses, BP.PD; 20/06180-4 - The Genomics for Climate Change Research Center, BP.TT; 20/09007-1 - The Genomics for Climate Change Research Center, BP.TT; 20/08947-0 - The Genomics for Climate Change Research Center, BP.TT; 20/02084-0 - Unraveling molecular mechanisms of plant adaptation in the extreme and biodiverse Brazilian campos rupestres, BP.DR; 19/24332-9 - The Genomics for Climate Change Research Center, BP.TT; 19/25388-8 - The Genomics for Climate Change Research Center, BP.TT; 19/23453-7 - The Genomics for Climate Change Research Center, BP.TT; 19/19856-9 - The Genomics for Climate Change Research Center, BP.TT; 19/19543-0 - Phylogenetic and functional diversity analysis of the microbiome of Vellozia species living in microhabitats with different nutritional availability, BP.TT; 19/20086-3 - The Genomics for Climate Change Research Center, BP.TT; 19/14087-7 - The Genomics for Climate Change Research Center, BP.TT; 18/25771-3 - The Genomics for Climate Change Research Center, BP.TT; 18/19100-9 - Designing a microbial synthetic community for improvement of drought stress tolerance in maize plants, BP.PD; 18/19099-0 - Genome assembly and annotation of two Brazilian native plants: unraveling adaptations to drought and phosphorus acquisition in Campos Rupestres, BP.TT; 18/20149-2 - Genetic transformation of corn with candidate genes responsive to the abiotic stresses associated with climate change, BP.PD; 18/18403-8 - Development of bioinformatics pipelines for identification of key microorganisms in drought stress resistence promotion, BP.TT; 18/20434-9 - The Genomics for Climate Change Research Center, BP.TT; 14/17634-5 - Mitochondria as a key element on stress response in plants, BP.PD - associated scholarships
• FAPESP publication: https://media.fapesp.br/bv/uploads/pdfs/FAPESP_Engineering_JMEqgBJ_21_21.pdf

Abstract

Global climate change poses a major threat to agricultural production and food security worldwide and especially in the tropics. Research and development efforts deploying advanced biotechnology tools for the genetic adaptation of crops to the underlying stresses are greatly concentrated in agricultural biotechnology transnationals. This proposal calls for an initiative jointly supported and staffed by EMBRAPA and UNICAMP and built upon a national and international network for the creation and long-term operation of a plant biotechnology pipeline to foster innovation and transfer of resulting biotechnological assets of climate change adaptation to society through the agricultural sector. (AU)

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARRETO, PEDRO; COUNAGO, RAFAEL M.; ARRUDA, PAULO. Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response. MITOCHONDRION, v. 53, p. 109-120, JUL 2020. (14/50897-0, 16/23218-0, 13/50724-5)

AQUINO, BRUNO; DA SILVA, VIVIANE C. H.; MASSIRER, KATLIN B.; ARRUDA, PAULO. Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding. BMC PLANT BIOLOGY, v. 20, n. 1, APR 15 2020. (14/50897-0, 16/23218-0)

CAMARGO, ANTONIO PEDRO; CORREA DE SOUZA, RAFAEL SOARES; COSTA, PATRICIA DE BRITTO; GERHARDT, ISABEL RODRIGUES; DANTE, RICARDO AUGUSTO; TEODORO, GRAZIELLE SALES; ABRAHAO, ANNA; LAMBERS, HANS; CARAZZOLLE, MARCELO FALSARELLA; HUNTEMANN, MARCEL; et al. Microbiomes of Velloziaceae from phosphorus-impoverished soils of the campos rupestres, a biodiversity hotspot. SCIENTIFIC DATA, v. 6, JUL 31 2019. (16/23218-0, 18/04240-0)

NAYFACH, STEPHEN; CAMARGO, ANTONIO PEDRO; SCHULZ, FREDERIK; ELOE-FADROSH, EMILEY; ROUX, SIMON; KYRPIDES, NIKOS C.. CheckV assesses the quality and completeness of metagenome-assembled viral genomes. NATURE BIOTECHNOLOGY, v. 39, n. 5, DEC 2020. (16/23218-0, 18/04240-0)

ARRUDA, PAULO; BARRETO, PEDRO. Lysine Catabolism Through the Saccharopine Pathway: Enzymes and Intermediates Involved in Plant Responses to Abiotic and Biotic Stress. FRONTIERS IN PLANT SCIENCE, v. 11, MAY 21 2020. (16/23218-0, 14/17634-5)

BARRETO, PEDRO; DAMBIRE, CHARLENE; SHARMA, GUNJAN; VICENTE, JORGE; OSBORNE, RORY; YASSITEPE, JULIANA; GIBBS, DANIEL J.; MAIA, IVAN G.; HOLDSWORTH, MICHAEL J.; ARUDA, PAULO. Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway. Current Biology, v. 32, n. 6, p. 14-pg., 2022-03-28. (15/24881-1, 14/17634-5, 16/23218-0, 17/22745-9)

JOSÉ HERNANDES-LOPES; JULIANA ERIKA DE CARVALHO TEIXEIRA YASSITEPE; ALESSANDRA KOLTUN; LAURENS PAUWELS; VIVIANE CRISTINA HEINZEN DA SILVA; RICARDO AUGUSTO DANTE; ISABEL RODRIGUES GERHARDT; PAULO ARRUDA. Genome editing in maize: Toward improving complex traits in a global crop. GENETICS AND MOLECULAR BIOLOGY, v. 46, n. 1, 2023-03-03. (16/23218-0, 18/06442-9, 21/08486-6)

HERNANDES-LOPES, JOSE; PINTO, MAISA SIQUEIRA; VIEIRA, LETICIA RIOS; MONTEIRO, PATRICIA BRANT; GERASIMOVA, SOPHIA V.; NONATO, JULIANA VIEIRA ALMEIDA; BRUNO, MARIA HELENA FAUSTINONI; VIKHOREV, ALEXANDER; RAUSCH-FERNANDES, FERNANDA; GERHARDT, ISABEL R.; et al. Enabling genome editing in tropical maize lines through an improved, morphogenic regulator-assisted transformation protocol. FRONTIERS IN GENOME EDITING, v. 5, p. 14-pg., 2023-12-07. (22/09418-7, 22/04441-0, 22/04929-3, 22/04930-1, 16/23218-0, 20/10677-1)

ALESSANDRA KOLTUN; PRISCILA ALVES DA SILVA; ISABELA YAMAUCHI TORRES; FERNANDO BONIFÁCIO-ANACLETO; JULIANA ERIKA DE CARVALHO TEIXEIRA YASSITEPE. Microsatellite markers in maize: challenges and guidelines for implementing multiplex SSR analyses. Crop Breeding and Applied Biotechnology, v. 24, n. 1, 2024-03-08. (16/23218-0)

BRAZ, GUILHERME T.; RIBOLDI, LUCAS B.; PINTO, MAISA S.; FORNI-MARTINS, ELIANA R.; YASSITEPE, JULIANA E. C. T.; DANTE, RICARDO A.; GERHARDT, ISABEL R.. Revisiting the cytogenetics of Vellozia Vand.: immunolocalization of KNL1 elucidates the chromosome number for the genus. Rev. bras. Bot., v. 48, n. 1, p. 8-pg., 2024-12-01. (21/00280-0, 16/23218-0, 22/04929-3, 21/00224-2)

CORREA DE SOUZA, RAFAEL SOARES; LEITE ARMANHI, JADERSON SILVEIRA; DAMASCENO, NATALIA DE BRITO; IMPERIAL, JUAN; ARRUDA, PAULO. Genome Sequences of a Plant Beneficial Synthetic Bacterial Community Reveal Genetic Features for Successful Plant Colonization. FRONTIERS IN MICROBIOLOGY, v. 10, AUG 13 2019. (18/19100-9, 16/04322-0, 16/23218-0, 16/23425-5)

YASSITEPE, JULIANA ERIKA DE CARVALHO TEIXEIRA; DA SILVA, VIVIANE CRISTINA HEINZEN; HERNANDES-LOPES, JOSE; DANTE, RICARDO AUGUSTO; GERHARDT, ISABEL RODRIGUES; FERNANDES, FERNANDA RAUSCH; DA SILVA, PRISCILA ALVES; VIEIRA, LETICIA RIOS; BONATTI, VANESSA; ARRUDA, PAULO. Maize Transformation: From Plant Material to the Release of Genetically Modified and Edited Varieties. FRONTIERS IN PLANT SCIENCE, v. 12, OCT 14 2021. (20/09007-1, 18/06442-9, 16/23218-0, 20/10677-1)

CAMARGO, ANTONIO P.; DE SOUZA, RAFAEL S. C.; JOSE, JULIANA; GERHARDT, ISABEL R.; DANTE, RICARDO A.; MUKHERJEE, SUPRATIM; HUNTEMANN, MARCEL; KYRPIDES, NIKOS C.; CARAZZOLLE, MARCELO F.; ARRUDA, PAULO. Plant microbiomes harbor potential to promote nutrient turnover in impoverished substrates of a Brazilian biodiversity hotspot. ISME Journal, v. N/A, p. 17-pg., 2022-12-20. (18/19100-9, 18/04240-0, 16/23218-0)

PINTO, OTAVIO HENRIQUE BEZERRA; BIAZOTTI, BARBARA BORT; DE SOUZA, RAFAEL SOARES CORREA; YASSITEPE, JULIANA ERIKA DE CARVALHO TEIXEIRA; ARRUDA, PAULO; DANTE, RICARDO AUGUSTO; GERHARDT, ISABEL RODRIGUES. Seasonal bacterial profiles of Vellozia with distinct drought adaptations in the megadiverse campos rupestres. SCIENTIFIC DATA, v. 12, n. 1, p. 9-pg., 2025-04-16. (16/23218-0, 22/08797-4, 18/19100-9)

BARRETO, PEDRO; KOLTUN, ALESSANDRA; NONATO, JULIANA; YASSITEPE, JULIANA; MAIA, IVAN DE GODOY; ARRUDA, PAULO. Metabolism and Signaling of Plant Mitochondria in Adaptation to Environmental Stresses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 19, p. 34-pg., 2022-10-01. (21/01003-0, 16/23218-0, 21/08486-6)

DE SOUZA, RAFAEL SOARES CORREA; ARMANHI, JADERSON SILVEIRA LEITE; ARRUDA, PAULO. From Microbiome to Traits: Designing Synthetic Microbial Communities for Improved Crop Resiliency. FRONTIERS IN PLANT SCIENCE, v. 11, AUG 27 2020. (16/23218-0, 18/19100-9, 18/18403-8)