Detection of QTL and search for causal mutations in candidate genes for meat tenderness in Nellore cattle

• Grant number: 14/23013-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 01, 2015
• End date: February 20, 2016
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Henrique Nunes de Oliveira
• Grantee: Camila Urbano Braz
• Supervisor: Jeremy Francis Taylor
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Institution abroad: University of Missouri, Columbia (UM), United States
• Associated to the scholarship: 13/00035-9 - Detection of QTLs and search for causal mutations in candidate gene for meat tenderness in Nellore cattle, BP.DR

Abstract

The beef cattle industry is of great economic importance to Brazil, however, despite the prominent position of national livestock in the economic scenario, it is characterized by low productivity and a large variation in the quality of meat produced, which compromises competitiveness of this market sector. The genetic improvement has been considered an important factor to increase this competitiveness and the molecular analyses of the genome of domestic animals begin to help solve some of the limitations of classical breeding methods. The development of high density panels of SNPs made it possible to find markers near to the causal mutations and statistical methods for genome wide analyzes allowed to search for QTLs along all the genome. However, the large quantity of available markers for association studies makes the power of each statistical test very small, then only genes with very important effects on traits can be identified in the small samples. Therefore, the aim of this study is to identify polymorphisms with significant effect on meat tenderness in Nellore cattle with subsequent sequencing of the identified regions and search for casual mutation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRAZ, CAMILA U.; TAYLOR, JEREMY F.; BRESOLIN, TIAGO; ESPIGOLAN, RAFAEL; FEITOSA, FABIELI L. B.; CARVALHEIRO, ROBERTO; BALDI, FERNANDO; DE ALBUQUERQUE, LUCIA G.; DE OLIVEIRA, HENRIQUE N.. Sliding window haplotype approaches overcome single SNP analysis limitations in identifying genes for meat tenderness in Nelore cattle. BMC GENETICS, v. 20, JAN 14 2019. (09/16118-5, 14/23013-3, 13/00035-9)

BRAZ, CAMILA URBANO; TAYLOR, JEREMY FRANCIS; DECKER, JARED EGAN; BRESOLIN, TIAGO; ESPIGOLAN, RAFAEL; GARCIA, DIOGO ANASTACIO; MANSAN GORDO, DANIEL GUSTAVO; BRAGA MAGALHAES, ANA FABRICIA; DE ALBUQUERQUE, LUCIA GALVDO; DE OLIVEIRA, HENRIQUE NUNES. Polymorphism analysis in genes associated with meat tenderness in Nelore cattle. META GENE, v. 18, p. 73-78, DEC 2018. (09/16118-5, 14/23013-3, 13/00035-9)